The primary aim of this K02 application is to further the applicant's scientific development in the area of treatment of drug dependent patients, particularly those who are """"""""dually diagnosed"""""""" with drug abuse and coexisting psychiatric illness. The major hypothesis guiding the applicant's current and planned research is that careful study of the relationship between substance use disorders and specific psychiatric disorders will inform and enhance treatment methods for dually diagnosed patients. This application is designed to strengthen the applicant's involvement in three MDA-funded projects (as PI or Co-PI), as well as several other funded projects as Co-Investigator or Consultant. The following funded projects are currently being pursued by the applicant: 1) a Stage 1 NIDA Behavioral Therapies Development Project to develop a relapse prevention group therapy manual for patients with coexisting bipolar disorder and substance use disorder (NIDA grant, PI); 2) the NIDA Collaborative Cocaine Treatment study, a multi-site randomized controlled trial, comparing 4 different behavioral treatments for cocaine dependent outpatients (NIDA grant, PI at the McLean/Massachusetts General Hospital site); and 3) a Stage 1 NIDA Behavioral Therapies Development study to develop and pilot-test a group cognitive-behavioral treatment manual for women with post-traumatic stress disorder and substance use disorder (NIDA grant, Co-PI). The applicant proposes to expand his research capabilities by integrating his clinical research with pre-clinical investigations conducted by investigators with complementary areas of research expertise. He will also be Co-Investigator or Consultant on other studies of comorbid substance use disorder and mood disorders, and consult at the Boston site of the NIDA/VA Medication Development project. Finally, the applicant will mentor young investigators who bring their expertise in other areas (e.g., neuroscience) to bear on drug abuse research projects.
| Crits-Christoph, Paul; Gallop, Robert; Gibbons, Mary Beth Connolly et al. (2013) Measuring Outcome in the Treatment of Cocaine Dependence. J Alcohol Drug Depend 1: |
| Levy, Boaz; Medina, Anna Marie; Manove, Emily et al. (2011) The characteristics of a discrete mood episode, neuro-cognitive impairment and re-hospitalization in bipolar disorder. J Psychiatr Res 45:1048-54 |
| Stulz, Niklaus; Thase, Michael E; Gallop, Robert et al. (2011) Psychosocial treatments for cocaine dependence: the role of depressive symptoms. Drug Alcohol Depend 114:41-8 |
| Stulz, Niklaus; Gallop, Robert; Lutz, Wolfgang et al. (2010) Examining differential effects of psychosocial treatments for cocaine dependence: an application of latent trajectory analyses. Drug Alcohol Depend 106:164-72 |
| Kalayasiri, Rasmon; Gelernter, Joel; Farrer, Lindsay et al. (2010) Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug Alcohol Depend 107:196-201 |
| DiClemente, Carlo C; Doyle, Suzanne R; Donovan, Dennis (2009) Predicting treatment seekers' readiness to change their drinking behavior in the COMBINE Study. Alcohol Clin Exp Res 33:879-92 |
| LoCastro, Joseph S; Youngblood, Marston; Cisler, Ron A et al. (2009) Alcohol treatment effects on secondary nondrinking outcomes and quality of life: the COMBINE study. J Stud Alcohol Drugs 70:186-96 |
| Kranzler, Henry R; Wilcox, Marsha; Weiss, Roger D et al. (2008) The validity of cocaine dependence subtypes. Addict Behav 33:41-53 |
| Meade, Christina S; Graff, Fiona S; Griffin, Margaret L et al. (2008) HIV risk behavior among patients with co-occurring bipolar and substance use disorders: associations with mania and drug abuse. Drug Alcohol Depend 92:296-300 |
| Donovan, Dennis M; Anton, Raymond F; Miller, William R et al. (2008) Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomes. J Stud Alcohol Drugs 69:5-13 |
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