This is a resubmission of a NIDA K02 Independent Investigator Award. The application proposes to provide the candidate, Tony P. George, M.D., with salary support over the next five years (2004-2009). Dr. George is currently an Assistant Professor in his sixth year on the psychiatry faculty at Yale University School of Medicine. Since joining the Yale faculty in 1998, Dr. George has developed a unique research program with a focus on understanding the effects of nicotine and tobacco use on cognitive and clinical function in patients with major psychiatric disorders, including schizophrenia. He has established an early record of significant publications, national recognition, and independent funding support in the area of nicotine and mental illness, including two NARSAD Young Investigator Awards, pilot studies in the Yale-VA MIRECC and the NIDA-funded Yale Transdisciplinary Tobacco Use Research Center, a Donaghue Medical Research Foundation grant, and two R01 grants from NIDA. The R01 grants have defined his translational focus on smoking and mental illness, and include a human laboratory study of smoking and cognitive function in schizophrenia (DA-14039, 20% effort with salary), and the development of a pharmacological treatment optimizing strategy for smoking cessation in schizophrenic patients using nicotine patch, bupropion and atypical antipsychotic drugs (DA-13672; 20% effort with salary). Accordingly, the receipt of a K02 award would allow him to: 1) continue to develop his independent research program at Yale and relieve the commitment of R01 funds from these projects to support his salary, and; 2) acquire knowledge and expertise in novel techniques from senior colleagues at Yale and elsewhere that are unfamiliar to him, including assessment of novel neuropsychological and psychophysiological endophenotypes, human molecular genetic and biochemical pharmacology techniques, and advanced biostatistical methods for smoking cessation clinical trials. To achieve these goals, he will organize a formal training program consisting of didactic instruction, guidance from senior colleagues and brief training experiences in the laboratories of collaborators working in these areas of interest. Ultimately, this K02 would support two new and integrated projects that will correlate neurocognitive, genetic and biochemical assessments with smoking cessation treatment response in schizophrenic patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02DA016611-03
Application #
7048664
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Aigner, Thomas G
Project Start
2004-07-01
Project End
2006-08-31
Budget Start
2006-04-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2006
Total Cost
$52,853
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Riad-Allen, Lilian; Dermody, Sarah Siodmok; Herman, Yarissa et al. (2017) Becoming tobacco-free: Changes in staff and patient attitudes and incident reports in a large academic mental health and addictions hospital. Am J Addict 26:183-191
Mackowick, Kristen M; Barr, Mera S; Wing, Victoria C et al. (2014) Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems. Prog Neuropsychopharmacol Biol Psychiatry 52:79-85
Schottenfeld, Richard S; Chawarski, Marek C; Cubells, Joseph F et al. (2014) Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug Alcohol Depend 136:36-42
Wing, Victoria C; Tang, Yi-Lang; Sacco, Kristi A et al. (2013) Effect of COMT Val(158)Met genotype on nicotine withdrawal-related cognitive dysfunction in smokers with and without schizophrenia. Schizophr Res 150:602-3
Morisano, Dominique; Wing, Victoria C; Sacco, Kristi A et al. (2013) Effects of tobacco smoking on neuropsychological function in schizophrenia in comparison to other psychiatric disorders and non-psychiatric controls. Am J Addict 22:46-53
Wu, Becky S; Weinberger, Andrea H; Mancuso, Enza et al. (2012) A Preliminary Feasibility Study of Varenicline for Smoking Cessation in Bipolar Disorder. J Dual Diagn 8:131-132
Mackowick, Kristen M; Lynch, Marie-Josee; Weinberger, Andrea H et al. (2012) Treatment of tobacco dependence in people with mental health and addictive disorders. Curr Psychiatry Rep 14:478-85
George, Tony P; Wu, Becky S; Weinberger, Andrea H (2012) A Review of Smoking Cessation in Bipolar Disorder: Implications for Future Research. J Dual Diagn 8:126-130
Wing, Victoria C; Bacher, Ingrid; Sacco, Kristi A et al. (2011) Neuropsychological performance in patients with schizophrenia and controls as a function of cigarette smoking status. Psychiatry Res 188:320-6
Moss, Taryn G; Weinberger, Andrea H; Vessicchio, Jennifer C et al. (2010) A tobacco reconceptualization in psychiatry: toward the development of tobacco-free psychiatric facilities. Am J Addict 19:293-311

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