Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02DK002465-01
Application #
2015657
Study Section
Special Emphasis Panel (SRC)
Project Start
1996-09-30
Project End
2001-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Andresen, Bradley T; Shome, Kuntala; Jackson, Edwin K et al. (2005) AT2 receptors cross talk with AT1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity. Am J Physiol Renal Physiol 288:F763-70
Andresen, Bradley T; Romero, Guillermo G; Jackson, Edwin K (2004) AT2 receptors attenuate AT1 receptor-induced phospholipase D activation in vascular smooth muscle cells. J Pharmacol Exp Ther 309:425-31
Andresen, Bradley T; Linnoila, Jenny J; Jackson, Edwin K et al. (2003) Role of EGFR transactivation in angiotensin II signaling to extracellular regulated kinase in preglomerular smooth muscle cells. Hypertension 41:781-6
Li, Hai-Sheng; Shome, Kuntala; Rojas, Raul et al. (2003) The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. BMC Cell Biol 4:13
Pathre, Purnima; Shome, Kuntala; Blumental-Perry, Anna et al. (2003) Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export. EMBO J 22:4059-69
Andresen, B T; Jackson, E K; Romero, G G (2001) Angiotensin II signaling to phospholipase D in renal microvascular smooth muscle cells in SHR. Hypertension 37:635-9
Shome, K; Rizzo, M A; Vasudevan, C et al. (2000) The activation of phospholipase D by endothelin-1, angiotensin II, and platelet-derived growth factor in vascular smooth muscle A10 cells is mediated by small G proteins of the ADP-ribosylation factor family. Endocrinology 141:2200-8
Rizzo, M A; Shome, K; Vasudevan, C et al. (1999) Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem 274:1131-9
Rizzo, M A; Romero, G (1998) The role of G proteins in insulin signalling. J Basic Clin Physiol Pharmacol 9:167-95
Vasudevan, C; Han, W; Tan, Y et al. (1998) The distribution and translocation of the G protein ADP-ribosylation factor 1 in live cells is determined by its GTPase activity. J Cell Sci 111 ( Pt 9):1277-85

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