Abstract

This proposal requests salary support for the applicant under the ADAMHA Research Scientist Development Program, Level II. It would enable him to assume a full-time appointment at New York State Psychiatric Institute, Department of Psychophysiology. The research plan, covering five years, concentrates on studies of behavioral and biological functions which comprise an organism's time-keeping repertoire. The experiments are based on behavioral, psychophysical and neuro-anatomical methods for analyzing a set of short-interval and circadian timing mechanisms, and their interactions. Specific topics include: a) Temporal Anticipation in the Short-Interval and Circadian Ranges, using exteroceptively cued feeding schedules; b) Short-Interval Timing with Circadian Activity Rhythms, using the Time-Left psychophysical method for assessing changes in the speed of an internal clock; c) Behavioral Analysis of Luminance Detectability Rhythms, using a signal-detection paradigm to study circadian oscillations in visual threshold; and c) Retinal Photoreceptor Organization and Circadian Variation in Visual Sensitivity, using coordinated anatomical and behavioral methods to specify the relation of rod outer-segment mechanisms to oscillating detection performance. Additionally, the candidate proposes to develop interactions with clinical research staff of the institute whose interests relate to circadian timing processes in patient populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH000461-05
Application #
3069814
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1983-12-01
Project End
1989-11-30
Budget Start
1989-01-01
Budget End
1989-11-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Terman, J S; Reme, C E; Terman, M (1993) Rod outer segment disk shedding in rats with lesions of the suprachiasmatic nucleus. Brain Res 605:256-64
Terman, M; Reme, C E; Wirz-Justice, A (1991) The visual input stage of the mammalian circadian pacemaking system: II. The effect of light and drugs on retinal function. J Biol Rhythms 6:31-48
Reme, C E; Wirz-Justice, A; Terman, M (1991) The visual input stage of the mammalian circadian pacemaking system: I. Is there a clock in the mammalian eye? J Biol Rhythms 6:5-29
Stewart, J W; Quitkin, F M; Terman, M et al. (1990) Is seasonal affective disorder a variant of atypical depression? Differential response to light therapy. Psychiatry Res 33:121-8
Terman, J S; Terman, M; Schlager, D et al. (1990) Efficacy of brief, intense light exposure for treatment of winter depression. Psychopharmacol Bull 26:3-11
Rosen, L N; Targum, S D; Terman, M et al. (1990) Prevalence of seasonal affective disorder at four latitudes. Psychiatry Res 31:131-44
Terman, M; Terman, J S; Quitkin, F M et al. (1989) Light therapy for seasonal affective disorder. A review of efficacy. Neuropsychopharmacology 2:1-22
Terman, M; Schlager, D; Fairhurst, S et al. (1989) Dawn and dusk simulation as a therapeutic intervention. Biol Psychiatry 25:966-70
Terman, M; Terman, J S; Quitkin, F M et al. (1988) Response of the melatonin cycle to phototherapy for Seasonal Affective Disorder. Short note. J Neural Transm 72:147-65
Terman, M (1988) On the question of mechanism in phototherapy for seasonal affective disorder: considerations of clinical efficacy and epidemiology. J Biol Rhythms 3:155-72

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