The long-term goal of the candidate's research program is to understand the biological basis for clinical heterogeneity in Alzheimer's disease in an effort to clarify the etiology(ies) of this disorder and its behavioral complications. This central theme is being pursued under the auspices of two ongoing NAMH-funded research grants. The first of these focuses on the clinical biology of a genetic factor that modifies the clinical expression of AD and whose segregation can be assessed through its effects on platelet membrane fluidity. The second approach employs a clinicopathological study of the brain morphological and neurochemical correlates of major depression in the context of AD. In addition, the candidate proposes incorporate APOE genotyping into the prospective longitudinal study of the AD high-risk cohort and ongoing genetic studies of the PME locus. Finally, the Candidate section provides a perspective on several innovative experimental approaches and methods that are in various stages of development in the candidate's laboratory.
| Zubenko, George S; Hughes 3rd, Hugh B (2010) Effects of the A(-115)G variant on CREB1 promoter activity in two brain cell lines: Interactions with gonadal steroids. Am J Med Genet B Neuropsychiatr Genet 153B:1365-72 |
| Maher, Brion S; Hughes 3rd, Hugh B; Zubenko, Wendy N et al. (2010) Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation of sex-specific effect. Am J Med Genet B Neuropsychiatr Genet 153B:10-6 |
| Zubenko, George S; Hughes 3rd, Hugh B; Zubenko, Wendy N (2010) D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: results at 14 years. Am J Med Genet B Neuropsychiatr Genet 153B:359-364 |
| Zubenko, George S; Hughes 3rd, Hugh B (2009) Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7. Genomics 93:376-82 |
