On the panic disorder project 21 multiplex pedigrees have been collected and typed for over 200RFLP markers. A candidate gene study of the adrenergic receptor loci was also completed. The next objectives will be to add five pedigrees per year over the next three years, and to type 300- 500 short tandem repeat markers covering the entire human genome. On the schizophrenia project, 15 multiplex pedigrees have been completed and two more will be completed shortly.Three regions of interest have been examined for linkage and no vulnerability loci were detected. These regions include chromosome 5q11-q13, 11q, and the pseudoautosomal region of the sex chromosomes. The next objectives are to add three pedigrees per year for the next three years, to study genomic regions of interest and candidate genes, and to pool the pedigrees with those of other groups in a collaborative genome search.
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| Philibert, Robert A; Nelson, Jeffrey J; Bedell, Bruce et al. (2003) Role of elastin polymorphisms in panic disorder. Am J Med Genet B Neuropsychiatr Genet 117B:7-10 |
| Crowe, R R; Goedken, R; Samuelson, S et al. (2001) Genomewide survey of panic disorder. Am J Med Genet 105:105-9 |
| Wang, Z; Valdes, J; Noyes, R et al. (1998) Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder. Am J Med Genet 81:228-34 |
| Garvey, M J; Crowe, R R; Wang, Z (1998) An association of NAG levels and a mutation of the CCK gene in panic disorder patients. Psychiatry Res 80:149-53 |
| Wang, Z W; Black, D; Andreasen, N C et al. (1993) A linkage study of chromosome 11q in schizophrenia. Arch Gen Psychiatry 50:212-6 |
| Schmidt, S M; Zoega, T; Crowe, R R (1993) Excluding linkage between panic disorder and the gamma-aminobutyric acid beta 1 receptor locus in five Icelandic pedigrees. Acta Psychiatr Scand 88:225-8 |
| Crowe, R R (1993) Candidate genes in psychiatry: an epidemiological perspective. Am J Med Genet 48:74-7 |
| Wang, Z W; Black, D; Andreasen, N et al. (1993) Pseudoautosomal locus for schizophrenia excluded in 12 pedigrees. Arch Gen Psychiatry 50:199-204 |
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