Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH000964-05
Application #
2240227
Study Section
Research Scientist Development Review Committee (MHK)
Project Start
1992-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Jiang, Xin; Manion, Brad D; Benz, Ann et al. (2003) Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. J Med Chem 46:5334-48
Covey, D F; Nathan, D; Kalkbrenner, M et al. (2000) Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia. J Pharmacol Exp Ther 293:1009-16
Covey, D F; Han, M; Kumar, A S et al. (2000) Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. J Med Chem 43:3201-4
Izumi, Y; Zorumski, C F (1999) Norepinephrine promotes long-term potentiation in the adult rat hippocampus in vitro. Synapse 31:196-202
Mennerick, S; Shen, W; Xu, W et al. (1999) Substrate turnover by transporters curtails synaptic glutamate transients. J Neurosci 19:9242-51
Kato, K; Li, S T; Zorumski, C F (1999) Modulation of long-term potentiation induction in the hippocampus by N-methyl-D-aspartate-mediated presynaptic inhibition. Neuroscience 92:1261-72
Shen, W; Mennerick, S; Zorumski, E C et al. (1999) Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. Neuropharmacology 38:267-71
Izumi, Y; Ishii, K; Katsuki, H et al. (1998) beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. J Clin Invest 101:1121-32
Izumi, Y; Zorumski, C F (1998) LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels. Neuroreport 9:3689-91
Mennerick, S; Zorumski, C F (1998) Measurement of glial transport currents in microcultures: application to excitatory neurotransmission. Methods Enzymol 296:632-45

Showing the most recent 10 out of 53 publications