This is an application for competing continuation of the Independent Scientist Award (K02), The Natural History of Dementia. The goals of the original award period included learning the theories, skills and methodologies necessary to analyze the results of longitudinal studies of progressive dementia. However, functional neuroimaging has played an increasingly important role in the applicant's developing research career. One strength of functional imaging lies in the ability to examine the breakdowns in the functional connectivity of cognitive brain systems, and how these breakdowns relate to cognitive function. The statistical techniques needed to accomplish these goals are new, and difficult to implement. Therefore, the purpose of this ISA is to free the applicant from administrative and clinical responsibilities to focus his attention on acquiring the theories and methodologies of higher- level statistical analysis of functional neuroimaging data. The research plan concerns the changes in cognition associated with advancing HIV infection and AIDS. Using HIV plus subjects recruited through a community-based sentinel network of primary care providers, we will track the neuropsychological, neurological, and psychosocial characteristics of subjects over a three year follow-up period. At study entry, and then at specific times during follow-up, subjects will complete structural and functional magnetic resonance imaging (MRI) scans; these data are the basis of the career development plan. The applicant will learn the techniques of measuring brain structure and function, and how to relate these to behavioral outcomes. Collaboration and structured laboratory visits with scientists at three research facilities will permit the applicant to learn and develop procedures such as structural equation modeling. The applicant will learn the skills needed to dissect the functional connectivity of brain systems in HIV/AIDS patients. These studies will provide critical information with regard to the breakdown in the integrity of cognitive processes in HIV- infected individuals. The ISA will permit the applicant to acquire state-of-the-art analytical strategies that will significantly enhance his continued career development.
| Lepore, N; Brun, C; Chou, Y Y et al. (2008) Generalized tensor-based morphometry of HIV/AIDS using multivariate statistics on deformation tensors. IEEE Trans Med Imaging 27:129-41 |
| Klunder, Andrea D; Chiang, Ming-Chang; Dutton, Rebecca A et al. (2008) Mapping cerebellar degeneration in HIV/AIDS. Neuroreport 19:1655-9 |
| Carmichael, Owen T; Kuller, L H; Lopez, O L et al. (2007) Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study. Neurobiol Aging 28:1316-21 |
| Carmichael, Owen T; Kuller, Lewis H; Lopez, Oscar L et al. (2007) Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia. Alzheimer Dis Assoc Disord 21:14-24 |
| Carmichael, Owen T; Kuller, Lewis H; Lopez, Oscar L et al. (2007) Ventricular volume and dementia progression in the Cardiovascular Health Study. Neurobiol Aging 28:389-97 |
| Chiang, Ming-Chang; Dutton, Rebecca A; Hayashi, Kiralee M et al. (2007) 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry. Neuroimage 34:44-60 |
| Lopez, O L; Becker, J T; Sweet, R A et al. (2006) Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease. Neurology 67:660-5 |
| Bhalla, Rishi K; Butters, Meryl A; Mulsant, Benoit H et al. (2006) Persistence of neuropsychologic deficits in the remitted state of late-life depression. Am J Geriatr Psychiatry 14:419-27 |
| Thompson, Paul M; Dutton, Rebecca A; Hayashi, Kiralee M et al. (2006) 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS. Neuroimage 31:12-23 |
| Lepore, Natasha; Brun, Caroline A; Chiang, Ming-Chang et al. (2006) Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS. Med Image Comput Comput Assist Interv 9:191-8 |
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