Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001174-03
Application #
2240654
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kagan, Bruce L; Hirakura, Yutaka; Azimov, Rustam et al. (2002) The channel hypothesis of Alzheimer's disease: current status. Peptides 23:1311-5
Hirakura, Yutaka; Carreras, Isabel; Sipe, Jean D et al. (2002) Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid 9:13-23
Hirakura, Y; Kagan, B L (2001) Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid 8:94-100
Kagan, B L; Hirakura, Y; Azimov, R et al. (2001) The channel hypothesis of Huntington's disease. Brain Res Bull 56:281-4
Hirakura, Y; Azimov, R; Azimova, R et al. (2000) Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases. J Neurosci Res 60:490-4
Hirakura, Y; Yiu, W W; Yamamoto, A et al. (2000) Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block). Amyloid 7:194-9
Chen, Q S; Kagan, B L; Hirakura, Y et al. (2000) Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 60:65-72
Schendel, S L; Azimov, R; Pawlowski, K et al. (1999) Ion channel activity of the BH3 only Bcl-2 family member, BID. J Biol Chem 274:21932-6
Mirzabekov, T A; Silberstein, A Y; Kagan, B L (1999) Use of planar lipid bilayer membranes for rapid screening of membrane active compounds. Methods Enzymol 294:661-74
Koo, S P; Bayer, A S; Kagan, B L et al. (1999) Membrane permeabilization by thrombin-induced platelet microbicidal protein 1 is modulated by transmembrane voltage polarity and magnitude. Infect Immun 67:2475-81

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