Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001174-03
Application #
2240654
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kagan, Bruce L; Hirakura, Yutaka; Azimov, Rustam et al. (2002) The channel hypothesis of Alzheimer's disease: current status. Peptides 23:1311-5
Hirakura, Yutaka; Carreras, Isabel; Sipe, Jean D et al. (2002) Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid 9:13-23
Hirakura, Y; Kagan, B L (2001) Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid 8:94-100
Kagan, B L; Hirakura, Y; Azimov, R et al. (2001) The channel hypothesis of Huntington's disease. Brain Res Bull 56:281-4
Hirakura, Y; Azimov, R; Azimova, R et al. (2000) Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases. J Neurosci Res 60:490-4
Hirakura, Y; Yiu, W W; Yamamoto, A et al. (2000) Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block). Amyloid 7:194-9
Chen, Q S; Kagan, B L; Hirakura, Y et al. (2000) Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 60:65-72
Hirakura, Y; Lin, M C; Kagan, B L (1999) Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red. J Neurosci Res 57:458-66
Kagan, B L; Leskin, G; Haas, B et al. (1999) Elevated lipid levels in Vietnam veterans with chronic posttraumatic stress disorder. Biol Psychiatry 45:374-7
Schendel, S L; Azimov, R; Pawlowski, K et al. (1999) Ion channel activity of the BH3 only Bcl-2 family member, BID. J Biol Chem 274:21932-6

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