Support is requested for a five-year ADAMHA Research Scientist Development Award, K02. The primary theme of the candidate's activities is to contribute to efforts to identify specific genetic loci that confer vulnerability to schizophrenia. The candidate is currently PI of an NIMH- funded study to screen the genome using a map of highly polymorphic DNA markers to identify a locus or loci linked to schizophrenia-related disorders in a sample of well-characterized multiplex families. Conceptual and methodological issues relevant to schizophrenia linkage studies are discussed, work to date is summarized, and progress toward collaboration is described. Additional planned areas of investigation include: study of schizophrenia in a more isolated population for future DNA association studies; the phenomenology of spectrum disorders in families of schizophrenic and affective probands; and dimensional approaches to classifying schizophrenic psychopathology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
7K02MH001207-05
Application #
6032293
Study Section
Special Emphasis Panel (SRCM (12))
Program Officer
Moldin, Steven Owen
Project Start
1995-08-01
Project End
1999-08-31
Budget Start
1998-11-11
Budget End
1999-08-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mcp Hahnemann University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19102
Mowry, B J; Holmans, P A; Pulver, A E et al. (2004) Multicenter linkage study of schizophrenia loci on chromosome 22q. Mol Psychiatry 9:784-95
Levinson, D F; Kirby, A; Slepner, S et al. (2001) Simulation studies of detection of a complex disease in a partially isolated population. Am J Med Genet 105:65-70