Abstract

This is an application for an ADAMHA Research Scientist Development Award (K02). The purpose of the Award is to foster the continued scientific development of the Principal Investigator (P.I.) in understanding the psychobiology of sleep related to psychiatric disorders. Research to be performed during the period of support includes a basic study of the acute effects of light on sleep and temperature in rats. Light therapy is being used with increasing frequency to treat a variety of conditions, including depression, circadian rhythm disorders, and sleep disturbances related to aging. Although the mechanisms for light entrainment of circadian rhythms have been studied extensively, the mechanisms for acute photic effects on sleep and temperature are unknown. A better understanding of light effects on the nervous system could make light a more powerful clinical tool.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
1K02MH001224-01
Application #
2240773
Study Section
Clinical Neuroscience Review Committee (CNR)
Project Start
1994-09-01
Project End
1999-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Psychiatry
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Benca, R M; Obermeyer, W H; Shelton, S E et al. (2000) Effects of amygdala lesions on sleep in rhesus monkeys. Brain Res 879:130-8
Benca, R M; Obermeyer, W H; Larson, C L et al. (1999) EEG alpha power and alpha power asymmetry in sleep and wakefulness. Psychophysiology 36:430-6
Miller, A M; Miller, R B; Obermeyer, W H et al. (1999) The pretectum mediates rapid eye movement sleep regulation by light. Behav Neurosci 113:755-65
Obermeyer, W H; Benca, R M (1999) REM sleep in response to light and dark in congenic albino and pigmented F344 rats. Sleep Res Online 2:83-8
Qiu, P; Chappell, R; Obermeyer, W et al. (1999) Modeling daily and subdaily cycles in rat sleep data. Biometrics 55:930-5
Miller, A M; Obermeyer, W H; Behan, M et al. (1998) The superior colliculus-pretectum mediates the direct effects of light on sleep. Proc Natl Acad Sci U S A 95:8957-62
Benca, R M; Gilliland, M A; Obermeyer, W H (1998) Effects of lighting conditions on sleep and wakefulness in albino Lewis and pigmented Brown Norway rats. Sleep 21:451-60
Benca, R M; Quintas, J (1997) Sleep and host defenses: a review. Sleep 20:1027-37
Obermeyer, W H; Benca, R M (1996) Effects of drugs on sleep. Neurol Clin 14:827-40
Benca, R M (1996) Sleep in psychiatric disorders. Neurol Clin 14:739-64

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