This is a request for a Career Development Award. The purpose of this application is to ensure the applicant adequate time for research, necessary to the continued development of her career as an independent investigator in statistical genetics with psychiatric applications, as well as to provide additional clinical training. The candidate is an expert in the application of statistical methods in psychiatric research. From 1990-1995 she has been supported by a prior NIMH Career Development Award. During the time she has acquired a broad background in human and psychiatric genetics and developed her skills in her own area of expertise, and she has already made several fundamental contributions to the field of statistical methods in psychiatric research. She has recently been recruited to join the faculty of The College of Medicine at the University of Iowa which has an outstanding research program in psychiatry and a strong commitment to genetics research. The discovery of genetic mechanisms underlying psychiatric disorders can facilitate diagnosis and prevention, aid in the development of more effective interventions, and broaden understanding of the contributions of both nature and nurture to psychopathology. Enormous technologic advances in recent years have made sophisticated modeling of complex genetic disorders feasible in principle. However, what is available in theory is not always feasible in practice. A fundamental source of difficulty involves proper procedures for sampling (ascertainment of families) and proper mathematical treatment of sampling in data analysis. Unresolved sampling problems can make planning and executing a genetic study of a complex disorder extremely difficult. The proposed research will address major sampling issues for complex genetic analysis using both analytic mathematical approaches and simulation studies. The candidate maintains ongoing established collaborations with clinicians on genetic studies of panic disorder, autism, and obsessive-compulsive disorder. All theoretical work will be both guided by and applied to the analysis of data from these studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001432-04
Application #
6185445
Study Section
Epidemiology and Genetics Review Committee (EPI)
Program Officer
Moldin, Steven Owen
Project Start
1997-05-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
4
Fiscal Year
2000
Total Cost
$99,517
Indirect Cost
Name
University of Iowa
Department
Genetics
Type
Schools of Public Health
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Wassink, Thomas H; Piven, Joseph; Vieland, Veronica J et al. (2005) Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene. Am J Med Genet B Neuropsychiatr Genet 136B:36-44
Wassink, Thomas H; Piven, Joseph; Vieland, Veronica J et al. (2002) Evaluation of FOXP2 as an autism susceptibility gene. Am J Med Genet 114:566-9
Bartlett, Christopher W; Flax, Judy F; Logue, Mark W et al. (2002) A major susceptibility locus for specific language impairment is located on 13q21. Am J Hum Genet 71:45-55
Collaborative Linkage Study of Autism (2001) An autosomal genomic screen for autism. Am J Med Genet 105:609-15
Collaborative Linkage Study of Autism (2001) Incorporating language phenotypes strengthens evidence of linkage to autism. Am J Med Genet 105:539-47
Vieland, V J; Wang, K; Huang, J (2001) Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data. Hum Hered 51:199-208
Piven, J (2001) The broad autism phenotype: a complementary strategy for molecular genetic studies of autism. Am J Med Genet 105:34-5
Wassink, T H; Piven, J; Vieland, V J et al. (2001) Evidence supporting WNT2 as an autism susceptibility gene. Am J Med Genet 105:406-13
Wassink, T H; Piven, J; Patil, S R (2001) Chromosomal abnormalities in a clinic sample of individuals with autistic disorder. Psychiatr Genet 11:57-63
Bradford, Y; Haines, J; Hutcheson, H et al. (2001) Incorporating language phenotypes strengthens evidence of linkage to autism. Am J Med Genet 105:539-47

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