This is a request for an NIMH Independent Scientist Award (ISA). It will enable the applicant to develop a research career plan which focuses on the use of prospective studies to: 1) increase the understanding of the relationships between biological factors and psychosocial functioning in schizophrenia: 2) to generate knowledge that integrates social and biological factors in a psychosocial rehabilitation framework that can be used to improve community-based rehabilitation service outcomes for individuals with schizophrenia. This research program builds on an ROl held by the applicant, as well as other studies on rehabilitative and prospective functional outcomes in schizophrenia. Seven specific career goals are outlined. These goals will be met through research activities and collaborations with senior scientists, classroom and technical training, writing of joint grant applications and participation in new scientific meetings. Plans for mentoring and participating in advanced scientific education are aimed at furthering the integration of biological factors into a more complete biosocial model of rehabilitation in schizophrenia. Blending biological factors with psychosocial rehabilitation models in schizophrenia will require the integration of a variety of theoretical and empirical themes in schizophrenia research. This application will use data from existing and planned studies on the effectiveness of community-based rehabilitative interventions, the etiology of schizophrenia, and on the relationship between biological factors and psychosocial functioning. It will also incorporate recent notions about the remediation of cognitive and psychophysiological deficits in schizophrenia. Stress-vulnerability models will be used as a guiding heuristic for this research development program. An Independent Scientist Award at this stage of the applicant's career will provide release from teaching and administrative responsibilities, and will provide the time and resources needed to capitalize on a superior network of senior investigators who will provide outstanding collaborative and training opportunities in this area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH001628-04
Application #
6391398
Study Section
Services Research Review Committee (SER)
Program Officer
Hohmann, Ann A
Project Start
1998-09-25
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
4
Fiscal Year
2001
Total Cost
$106,515
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Social Work
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Brekke, John; Kay, Diane D; Lee, Kimmy S et al. (2005) Biosocial pathways to functional outcome in schizophrenia. Schizophr Res 80:213-25
Brekke, John S; Nakagami, Eri; Kee, Kimmy S et al. (2005) Cross-ethnic differences in perception of emotion in schizophrenia. Schizophr Res 77:289-98
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Brekke, J S; Prindle, C; Bae, S W et al. (2001) Risks for individuals with schizophrenia who are living in the community. Psychiatr Serv 52:1358-66