Dr. Ford' s career to date incorporates applications of electrophysiological techniques to illuminate cognitive and experiential aspects of schizophrenia not readily amenable to behavioral assessments. Her career goals for the K02 Award include: * Enhancing skills in design of functional magnetic resonance (fMRI) studies; * Enhancing skills for analysis of event-related potential (ERP) data; * Exploring ways to integrate fMRI and ERP data; * Acquiring skills for simultaneous recording of fMRI and ERP; * Acquiring skills in magnetoencephalography (MEG) recording and analysis; * Improving skills in clinical assessment of psychotic symptoms. These skills will be applied to ongoing studies designed to test hypotheses about the contribution of corollary discharge deficits to the experience of hallucinations and response processing deficits in patients with schizophrenia. Specific work proposed includes: * Use ERPs in two separate experiments to directly compare two manifestations of failure of corollary discharge (N1 non-suppression and error-related negativity [ERN] non-suppression) in patients with schizophrenia, with and without hallucinations; * Directly compare these phenomena using fMRI in the same subjects; * Integrate ERP and fMRI data from these two experiments; * Add a clinical comparison group of psychotic depressed patients with and without hallucinations; * Perform a parallel study to explore the potential of magnetoencephalogram (MEG) for assessing the source of auditory N1m, an analog of the auditory N1. Stanford University provides a technologically and intellectually rich environment for extending Dr. Ford's research into new directions. The facilities and staff of the Department of Psychiatry, Lucas Imaging Center, as well as of the Bio-X program at Stanford will continue to be available to Dr. Ford. These will be supplemented by collaborations with investigators at University of California, San Francisco to conduct MEG studies, University of Pennsylvania to study multi-lead EEG processing, and Institute for Psychiatry, London to study phenomenology of hallucinations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH067967-05
Application #
7115852
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (02))
Program Officer
Meinecke, Douglas L
Project Start
2003-09-01
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
5
Fiscal Year
2006
Total Cost
$152,388
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Biagianti, Bruno; Roach, Brian J; Fisher, Melissa et al. (2017) Trait aspects of auditory mismatch negativity predict response to auditory training in individuals with early illness schizophrenia. Neuropsychiatr Electrophysiol 3:
Perez, Veronica B; Woods, Scott W; Roach, Brian J et al. (2014) Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biol Psychiatry 75:459-69
Butler, Pamela D; Chen, Yue; Ford, Judith M et al. (2012) Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS. Schizophr Bull 38:81-91
Whitford, Thomas J; Ford, Judith M; Mathalon, Daniel H et al. (2012) Schizophrenia, myelination, and delayed corollary discharges: a hypothesis. Schizophr Bull 38:486-94
Perez, Veronica B; Ford, Judith M; Roach, Brian J et al. (2012) Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis. Schizophr Bull 38:1216-24
Ford, Judith M; Perez, Veronica B; Mathalon, Daniel H (2012) Neurophysiology of a possible fundamental deficit in schizophrenia. World Psychiatry 11:58-60
Ford, Judith M; Mathalon, Daniel H (2012) Anticipating the future: automatic prediction failures in schizophrenia. Int J Psychophysiol 83:232-9
Gunduz-Bruce, Handan; Reinhart, Robert M G; Roach, Brian J et al. (2012) Glutamatergic modulation of auditory information processing in the human brain. Biol Psychiatry 71:969-77
Perez, Veronica B; Ford, Judith M; Roach, Brian J et al. (2012) Error monitoring dysfunction across the illness course of schizophrenia. J Abnorm Psychol 121:372-87
Whitford, T J; Mathalon, D H; Shenton, M E et al. (2011) Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia. Psychol Med 41:959-69

Showing the most recent 10 out of 23 publications