The overarching aim of this program of research is to use Magnetic Resonance Imaging (MRI) methodologies to identify the neurobiological basis of developmental neuropsychiatric disorders, and in several disease areas in particular: 1) Disorders of impulse control, including Tourette's syndrome (TS), Obsessive-Compulsive Disorder (OCD), and Attention-Deficit/Hyperactivity Disorder (ADHD); 2) Conditions that confer risk for disturbances in development of the neonatal brain, including premature birth and prenatal exposure to drugs of abuse; and 3) Affective Disorders. A substantial portion of his work also involves the development of new methods for processing MRI data and for translational research involving behavioral neuroscience paradigms within the MRI scanner, as well as mentoring junior investigators in the application of neuroimaging methodologies to the study of childhood psychiatric disorders. The immediate aims of this Career Development Award (K02) are to (1) obtain sufficient salary support to allow the applicant to continue using MRI methods to define the neurobiological bases of childhood neuropsychiatric disorders; (2) free the applicant of substantial clinical, teaching, and administrative responsibilities, thereby permitting a greater focus of time and energy on research activities; (3) provide the applicant with the opportunity to develop skill sets in MR Spectroscopy (MRS), an MRI modality with which he has only limited experience, but one that promises to reveal further the neurochemical underpinnings of morphological and functional disturbances that the applicant has helped to define in TS, OCD, and ADHD; and (4) conduct an already-funded morphometric study (R01) of 620 children and adults with TS, OCD, or ADHD and to correlate those morphological measures with immunological, neurohumoral, neuropsychological, and family history data.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02MH074677-04
Application #
7432509
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Friedman-Hill, Stacia
Project Start
2005-09-15
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
4
Fiscal Year
2008
Total Cost
$122,861
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Bansal, Ravi; Peterson, Bradley S (2018) Cluster-level statistical inference in fMRI datasets: The unexpected behavior of random fields in high dimensions. Magn Reson Imaging 49:101-115
Bansal, R; Hellerstein, D J; Peterson, B S (2018) Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness. Mol Psychiatry 23:375-383
Desai, Jay; Huo, Yuankai; Wang, Zhishun et al. (2017) Reduced perfusion in Broca's area in developmental stuttering. Hum Brain Mapp 38:1865-1874
Marsh, Rachel; Tau, Gregory Z; Wang, Zhishun et al. (2015) Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. Am J Psychiatry 172:383-92
Peterson, Bradley S; Rauh, Virginia A; Bansal, Ravi et al. (2015) Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry 72:531-40
Peterson, Bradley S; Wang, Zhishun; Horga, Guillermo et al. (2014) Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder. JAMA Psychiatry 71:136-48
Posner, Jonathan; Marsh, Rachel; Maia, Tiago V et al. (2014) Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp 35:2852-60
Bansal, Ravi; Hao, Xuejun; Liu, Jun et al. (2014) Using Copula distributions to support more accurate imaging-based diagnostic classifiers for neuropsychiatric disorders. Magn Reson Imaging 32:1102-13
Marsh, Rachel; Horga, Guillermo; Parashar, Nidhi et al. (2014) Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder. Biol Psychiatry 75:615-22
Tseng, Angela; Bansal, Ravi; Liu, Jun et al. (2014) Using the circumplex model of affect to study valence and arousal ratings of emotional faces by children and adults with autism spectrum disorders. J Autism Dev Disord 44:1332-46

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