Hyperactive behavior (HB) is a vexing problem for a large number of children with and without a formal diagnosis of attention- deficit/hyperactivity disorder (ADHD). Although the causes of HB are poorly understood, one such cause may be primary sleep disorders; the small subset of children seen at sleep centers often have HB that resolves when a sleep disorder is identified and treated. Arising from this observation, the long-term objective of this application is to examine the impact of undiagnosed sleep disorders on HB in children. The research plan starts with a cross-sectional survey of 1000 patients at a general pediatrics clinic to test for associations between HB and symptoms of sleep disorders in children aged 2-14 years. Subjects thus found to be hyperactive will be tested to establish the frequency of sleep disorders. A randomized controlled clinical trial will then be performed to determine whether HB improves when children's sleep disorders are treated. Finally, the cohort of children originally identified as being free of HB will be reassessed 4 years later to determine which symptoms of sleep disorder might predict later development of HB. The candidate for this research career award is a tenure-tract assistant professor in neurology with special expertise in sleep medicine who seeks to establish a clinical research career at the interface of the two disciplines. He plans to acquire additional expertise in children's sleep and behavior and to initiate prospective research in a promising new area. His long-term goals are to focus on neurological and behavioral effects of sleep-related breathing disorder to develop optimal standards and techniques for diagnosis of these conditions and to improve effectiveness of their treatment. To foster these goals, the University of Michigan offers internationally recognized colleagues and state-of-the-art facilities for pediatric polysomnography. The Department of Neurology provides an unwavering commitment to the development of the P.I. has an independent investigator, including funds for the candidate's graduate studies at the School of Public Health in clinical research design and biostatistics (M.S. expected in May 1997). This training, combined with prior education in neurology and sleep disorders under distinguished clinicians and researchers, leaves the candidate will-prepared for a successful independent research center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Scientist Development Award - Research (K02)
Project #
5K02NS002009-04
Application #
6187564
Study Section
NST-2 Subcommittee (NST)
Program Officer
Finkelstein, Robert
Project Start
1997-09-30
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$83,173
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Neurology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Giordani, Bruno; Hodges, Elise K; Guire, Kenneth E et al. (2008) Neuropsychological and behavioral functioning in children with and without obstructive sleep apnea referred for tonsillectomy. J Int Neuropsychol Soc 14:571-81
Dillon, James E; Blunden, Sarah; Ruzicka, Deborah L et al. (2007) DSM-IV diagnoses and obstructive sleep apnea in children before and 1 year after adenotonsillectomy. J Am Acad Child Adolesc Psychiatry 46:1425-36
Chervin, Ronald D; Weatherly, Robert A; Ruzicka, Deborah L et al. (2006) Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical care. Sleep 29:495-503
Chervin, Ronald D; Ruzicka, Deborah L; Giordani, Bruno J et al. (2006) Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy. Pediatrics 117:e769-78
Chervin, Ronald D; Ruzicka, Deborah L; Archbold, Kristen Hedger et al. (2005) Snoring predicts hyperactivity four years later. Sleep 28:885-90
Chervin, Ronald D; Burns, Joseph W; Subotic, Nikolas S et al. (2004) Correlates of respiratory cycle-related EEG changes in children with sleep-disordered breathing. Sleep 27:116-21
Chervin, Ronald D; Burns, Joseph W; Subotic, Nikolas S et al. (2004) Method for detection of respiratory cycle-related EEG changes in sleep-disordered breathing. Sleep 27:110-5
Weatherly, Robert A; Ruzicka, Deborah L; Marriott, Deanna J et al. (2004) Polysomnography in children scheduled for adenotonsillectomy. Otolaryngol Head Neck Surg 131:727-31
Chervin, Ronald D; Dillon, James E; Archbold, Kristen Hedger et al. (2003) Conduct problems and symptoms of sleep disorders in children. J Am Acad Child Adolesc Psychiatry 42:201-8
Chervin, Ronald D; Clarke, Dave F; Huffman, Jennifer L et al. (2003) School performance, race, and other correlates of sleep-disordered breathing in children. Sleep Med 4:21-7

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