Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Modified Research Career Development Award (K04)
Project #
3K04AG000334-01S1
Application #
3070514
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1986-06-01
Project End
1991-05-31
Budget Start
1986-12-05
Budget End
1987-05-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Oregon State University
Department
Type
Schools of Arts and Sciences
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
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Schmidt, E E; Merrill, G F (1991) Changes in dihydrofolate reductase (DHFR) mRNA levels can account fully for changes in DHFR synthesis rates during terminal differentiation in a highly amplified myogenic cell line. Mol Cell Biol 11:3726-34
Schmidt, E E; Owen, R A; Merrill, G F (1990) An intragenic region downstream from the dihydrofolate reductase promoter is required for replication-dependent expression. J Biol Chem 265:17397-400
Schmidt, E E; Merrill, G F (1989) Transcriptional repression of the mouse dihydrofolate reductase gene during muscle cell commitment. J Biol Chem 264:21247-56
Gross, M K; Merrill, G F (1989) Thymidine kinase synthesis is repressed in nonreplicating muscle cells by a translational mechanism that does not affect the polysomal distribution of thymidine kinase mRNA. Proc Natl Acad Sci U S A 86:4987-91
Schmidt, E E; Merrill, G F (1989) Maintenance of dihydrofolate reductase enzyme after disappearance of DHFR mRNA during muscle cell differentiation. In Vitro Cell Dev Biol 25:697-704
Merrill, G F (1989) Clonal derivation of a rat muscle cell strain that forms contraction-competent myotubes. In Vitro Cell Dev Biol 25:471-6
Gross, M K; Merrill, G F (1988) Regulation of thymidine kinase protein levels during myogenic withdrawal from the cell cycle is independent of mRNA regulation. Nucleic Acids Res 16:11625-43
Gross, M K; Kainz, M S; Merrill, G F (1987) The chicken thymidine kinase gene is transcriptionally repressed during terminal differentiation: the associated decline in TK mRNA cannot account fully for the disappearance of TK enzyme activity. Dev Biol 122:439-51
Gross, M K; Kainz, M S; Merrill, G F (1987) Introns are inconsequential to efficient formation of cellular thymidine kinase mRNA in mouse L cells. Mol Cell Biol 7:4576-81