This is an RCDA application to provide salary support for the candidate's scientific growth in the area of aging, exercise and energy metabolism. The major hypotheses are: (1) decreases in energy intake and expenditure, and increases in body fat and loss of muscle mass are mediated by a reduction in physical activity, and not to an effect of aging; (2) deleterious changes in energy intake, expenditure and body composition are reversible by exercise training, and (3) sympathetic nervous system activity (SNSa) plays an important role in the regulation of these physiological processes. The applicant's immediate goals include: (1) to successfully complete and publish the results of the proposed experiments in respected journals, (2) to establish an independently funded catecholamine laboratory and, (3) to successfully compete for a R01 award. The applicant's long-term objectives are: (1) to understand the mechanism of """"""""muscle wasting"""""""" in aging individuals, and the potential role of exercise in reversing this process, (2) to define daily energy requirements in elderly persons varying in health and nutritional status by direct measurement of daily energy expenditure and body composition, and (3) to understand the regulation of SNSa and fat metabolism during submaximal exercise in elderly people. Laboratory techniques to be learned are directly applicable to achieving his long-term objectives. These techniques include: in vivo assessment of triglyceride/fatty acid cycling, skeletal muscle protein synthesis and microneurographic recording of sympathetic action potentials.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Modified Research Career Development Award (K04)
Project #
5K04AG000564-04
Application #
2048330
Study Section
Special Emphasis Panel (SSS (S1))
Project Start
1992-09-01
Project End
1997-08-31
Budget Start
1994-09-30
Budget End
1995-08-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Poehlman, E T; Dvorak, R V (2000) Energy expenditure, energy intake, and weight loss in Alzheimer disease. Am J Clin Nutr 71:650S-655S
Dvorak, R V; Tchernof, A; Starling, R D et al. (2000) Respiratory fitness, free living physical activity, and cardiovascular disease risk in older individuals: a doubly labeled water study. J Clin Endocrinol Metab 85:957-63
Tomoyasu, N J; Toth, M J; Poehlman, E T (1999) Misreporting of total energy intake in older men and women. J Am Geriatr Soc 47:710-5
Gardner, A W; Poehlman, E T (1998) Assessment of free-living daily physical activity in older claudicants: validation against the doubly labeled water technique. J Gerontol A Biol Sci Med Sci 53:M275-80
Dvorak, R V; Calles-Escandon, J; Poehlman, E T (1998) Measurement and prediction of sympathetic nervous system activity in humans. Life Sci 62:1397-406
Dvorak, R V; Poehlman, E T (1998) Norepinephrine kinetics in older women: relationship to physical activity and blood pressure. Exp Gerontol 33:507-16
Dvorak, R V; Poehlman, E T (1998) Appendicular skeletal muscle mass, physical activity, and cognitive status in patients with Alzheimer's disease. Neurology 51:1386-90
Poehlman, E T; Toth, M J; Ades, P A et al. (1997) Gender differences in resting metabolic rate and noradrenaline kinetics in older individuals. Eur J Clin Invest 27:23-8
Nicklas, B J; Toth, M J; Goldberg, A P et al. (1997) Racial differences in plasma leptin concentrations in obese postmenopausal women. J Clin Endocrinol Metab 82:315-7
Poehlman, E T; Toth, M J; Ades, P A et al. (1997) Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest 27:322-6

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