Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Modified Research Career Development Award (K04)
Project #
5K04AI001161-04
Application #
2057258
Study Section
Immunobiology Study Section (IMB)
Project Start
1993-07-15
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Nemazee, D (1998) Theoretical limits to massive receptor editing in immature B cells. Curr Top Microbiol Immunol 229:163-71
Melamed, D; Benschop, R J; Cambier, J C et al. (1998) Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92:173-82
Kouskoff, V; Famiglietti, S; Lacaud, G et al. (1998) Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med 188:1453-64
Melamed, D; Kench, J A; Grabstein, K et al. (1997) A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors. J Immunol 159:1233-9
Lang, J; Arnold, B; Hammerling, G et al. (1997) Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J Exp Med 186:1513-22
Melamed, D; Nemazee, D (1997) Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. Proc Natl Acad Sci U S A 94:9267-72
Hertz, M; Nemazee, D (1997) BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro. Immunity 6:429-36
Nemazee, D (1996) Antigen receptor 'capacity' and the sensitivity of self-tolerance. Immunol Today 17:25-9
Lang, J; Jackson, M; Teyton, L et al. (1996) B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J Exp Med 184:1685-97
Rubio, C F; Kench, J; Russell, D M et al. (1996) Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes. J Immunol 157:65-71

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