Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
1K04CA001230-01
Application #
3071773
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1987-04-01
Project End
1992-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kensler, T W; Davidson, N E; Groopman, J D et al. (1993) Chemoprotection by inducers of electrophile detoxication enzymes. Basic Life Sci 61:127-36
Groopman, J D; DeMatos, P; Egner, P A et al. (1992) Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis 13:101-6
Kensler, T W; Groopman, J D; Eaton, D L et al. (1992) Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione. Carcinogenesis 13:95-100
Akman, S A; Doroshow, J H; Kensler, T W (1992) Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189. Carcinogenesis 13:1783-7
Roebuck, B D; Liu, Y L; Rogers, A E et al. (1991) Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Res 51:5501-6
Seed, J L; Kensler, T W; Elia, M et al. (1990) Induction of sister-chromatid exchanges by polycyclic aromatic hydrocarbons following metabolic activation with phorbol ester-stimulated human polymorphonuclear leukocytes. Res Commun Chem Pathol Pharmacol 67:349-60
Davidson, N E; Egner, P A; Kensler, T W (1990) Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver. Cancer Res 50:2251-5
Swauger, J E; Dolan, P M; Kensler, T W (1990) Role of free radicals in tumor promotion and progression by benzoyl peroxide. Prog Clin Biol Res 340D:143-52
Taffe, B G; Zweier, J L; Pannell, L K et al. (1989) Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin. Carcinogenesis 10:1261-8
Liu, Y L; Roebuck, B D; Yager, J D et al. (1988) Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat. Toxicol Appl Pharmacol 93:442-51

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