Abstract

The overall objective of the studies outlined in the application is to obtain a quantitative and fundamental physicochemical understanding of the interactions of immune complexes (IC) with immunoadsorbents. Special emphasis will be placed upon (1) obtaining a basic understanding of the complex interactions in solution involving antigen, antibody complement, and various other plasma borne molecules; (2) defining and quantifying the reactions in solution between IC both reactive and non-reactive towards complement components; and (3) investigating the reactions occurring during immunosorption of immune complexes with a variety of receptor molecules bound to solid supports and with cells which have receptors for immune complexes. Techniques to be used include classical and dynamic light scattering. HPLC, radioimmumnoassays, and electron microscopy. Experiments will be carried out with model immune complexes and with immune complexes isolated from sera of feline leukemia virus-infected cats. The proposed research will enhance our understanding of IC formation and behavior in the presence of complement and specific blood cells, and may provide a rational basis for future development and design of immunoadsorption techniques which may be applied diagnostically or therapeutically to a variety of disease states.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
5K04CA001401-02
Application #
3071904
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1989-02-01
Project End
1994-01-31
Budget Start
1990-02-01
Budget End
1991-01-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Type
Schools of Engineering
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Lewis, Terri; McElroy, Erika; Harlaar, Nicole et al. (2016) Does the impact of child sexual abuse differ from maltreated but non-sexually abused children? A prospective examination of the impact of child sexual abuse on internalizing and externalizing behavior problems. Child Abuse Negl 51:31-40
Runyan, Desmond K; Cox, Christine E; Dubowitz, Howard et al. (2005) Describing maltreatment: do child protective service reports and research definitions agree? Child Abuse Negl 29:461-77
Dubowitz, Howard; Lane, Wendy; Ross, Kimberly et al. (2004) The involvement of low-income African American fathers in their children's lives, and the barriers they face. Ambul Pediatr 4:505-8
Black, Maureen M; Papas, Mia A; Hussey, Jon M et al. (2002) Behavior problems among preschool children born to adolescent mothers: effects of maternal depression and perceptions of partner relationships. J Clin Child Adolesc Psychol 31:16-26
Dubowitz, Howard; Papas, Mia A; Black, Maureen M et al. (2002) Child neglect: outcomes in high-risk urban preschoolers. Pediatrics 109:1100-7
Dubowitz, H; Black, M M; Kerr, M A et al. (2001) Type and timing of mothers' victimization: effects on mothers and children. Pediatrics 107:728-35
Dubowitz, H; Black, M M; Cox, C E et al. (2001) Father involvement and children's functioning at age 6 years: a multisite study. Child Maltreat 6:300-9
Dubowitz, H; Black, M M; Kerr, M A et al. (2000) Fathers and child neglect. Arch Pediatr Adolesc Med 154:135-41
Black, M M; Dubowitz, H; Starr Jr, R H (1999) African American fathers in low income, urban families: development, behavior, and home environment of their three-year-old children. Child Dev 70:967-78
Black, M M; Krishnakumar, A (1999) Predicting longitudinal growth curves of height and weight using ecological factors for children with and without early growth deficiency. J Nutr 129:539S-543S

Showing the most recent 10 out of 18 publications