Abstract

Proposed here are a series of studies, analyses of previously collected data, examining the role of dietary factors in carcinogenesis. Two types of studies are proposed: 1) case-control and 2) cohort. For the case- control studies, analyses will examine the role of dietary intake in premenopausal breast cancer, endometrial cancer and prostatic cancer. In particular, the association of fat, kilocalories, carotenoids, vitamins A, C and E, fiber, zinc and cruciferous vegetables will be investigated. In addition, data on the controls from the case-control studies will be utilized to examine the colinearity among other risk factors and dietary practices. For the cohort study, 56,000 older-term New York State residents, both males and females who completed a short questionnaire in 1980 regarding their usual dietary intake and data such as age, age at first birth and smoking practices have been followed. Sufficient cases have now accrued to allow for analysis of dietary factors in cancer of the lung, colo, rectum, ovary, endometrium and prostate. These investigations, combining retrospective, cross-sectional and prospective designs, will help to elucidate the role of dietary intake and nutrient status in carcinogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
5K04CA001633-02
Application #
3071991
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1992-08-01
Project End
1997-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
State University of New York at Buffalo
Department
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260

  Publications

Hakman, Melissa; Chaffin, Mark; Funderburk, Beverly et al. (2009) Change trajectories for parent-child interaction sequences during parent-child interaction therapy for child physical abuse. Child Abuse Negl 33:461-70
Ambrosone, C B; Coles, B F; Freudenheim, J L et al. (1999) Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants. J Nutr 129:565S-568S
Ambrosone, C B; Freudenheim, J L; Thompson, P A et al. (1999) Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Res 59:602-6
Mendola, P; Moysich, K B; Freudenheim, J L et al. (1998) Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1. Epidemiology 9:666-8
Ambrosone, C B; Freudenheim, J L; Sinha, R et al. (1998) Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms. Int J Cancer 75:825-30
Petralia, S A; Vena, J E; Freudenheim, J L et al. (1998) Breast cancer risk and lifetime occupational history: employment in professional and managerial occupations. Occup Environ Med 55:43-8
Thompson, P A; Shields, P G; Freudenheim, J L et al. (1998) Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk. Cancer Res 58:2107-10
Freudenheim, J L; Marshall, J R; Vena, J E et al. (1997) Lactation history and breast cancer risk. Am J Epidemiol 146:932-8
Schunemann, H J; Muti, P; Freudenheim, J L et al. (1997) Oxidative stress and lung function. Am J Epidemiol 146:939-48
Bandera, E V; Freudenheim, J L; Marshall, J R et al. (1997) Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States) Cancer Causes Control 8:828-40

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