My immediate and long-term career objectives are to actively engage in research in the area of carcinogenesis. I plan to study the mechanisms by which peroxisome proliferators induce hepatocellular carcinomas. I am testing the hypotheses that peroxisome proliferators induce hepatocellular carcinomas by 1) inducing oxidative DNA damage, 2) increasing long-term cell proliferation, or 3) altering eicosanoid metabolism. We will compare ciprofibrate with the unusual peroxisome proliferator perfluorodecanoic acid, which, unlike most other peroxisome proliferators, inhibits peroxisomal beta-oxidation, increases glutathione concentrations, and does not have promoting activity, for their abilities to produce the above changes. Transgenic mice will be produced with liver specific expression of peroxisome proliferator-induced genes so that the genetic change that produces biochemical changes induced by peroxisome proliferators can be identified.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Modified Research Career Development Award (K04)
Project #
5K04CA001688-03
Application #
2084290
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1992-08-01
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506