This project proposes to do an in-depth evaluation of patients with Meniere's disease from the audiological, auditory physiological and vestibular standpoints. Cochlear function will be qualified using routine audiometry, electrocochleography, auditory brain-stem responses, and otoacoustic emissions in a pre-and postglycerol ingestion paradigm. Vestibular function will be quantified using computerized measures of vestibulo-ocular and vestigulospinal reflexes. Patients will be randomized into two groups: 1) endolymphatic sac-mastoid shunting and 2) controls. Long term follow-up will use same measures with occasional glycerol challenges over a two year period. By systematically applying these objective measures of cochlear and vestibular function, we should be able to 1) reliably group patients with Meniere's disease into various categories according to sites of involvement of the end organ, i.e., sensory hair cells vs neural elements, and 2) define the diagnosis and natural course of the disease and test the validity of the endolymphatic sac-mastoid shunt. Ultimately, it should be possible to outline objective indicators that can predict success of various treatments in this disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Modified Research Career Development Award (K04)
Project #
5K04DC000048-04
Application #
3072068
Study Section
Hearing Research Study Section (HAR)
Project Start
1990-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Francis, Howard W; Scott, John C; Manis, Paul B (2002) Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. Brain Res 951:9-22
Molitor, S C; Manis, P B (1999) Voltage-gated Ca2+ conductances in acutely isolated guinea pig dorsal cochlear nucleus neurons. J Neurophysiol 81:985-98
Cunningham, A M; Manis, P B; Reed, R R et al. (1999) Olfactory receptor neurons exist as distinct subclasses of immature and mature cells in primary culture. Neuroscience 93:1301-12
Harty, T P; Manis, P B (1998) Kinetic analysis of glycine receptor currents in ventral cochlear nucleus. J Neurophysiol 79:1891-901
Molitor, S C; Manis, P B (1997) Evidence for functional metabotropic glutamate receptors in the dorsal cochlear nucleus. J Neurophysiol 77:1889-905
Fitzakerley, J L; Schaefer, K L; Kitko, R A et al. (1997) Properties of cochlear nucleus neurons in primary culture. Hear Res 114:148-68
Harty, T P; Manis, P B (1996) Glycine-evoked currents in acutely dissociated neurons of the guinea pig ventral cochlear nucleus. J Neurophysiol 75:2300-11
Manis, P B; Molitor, S C (1996) N-methyl-D-aspartate receptors at parallel fiber synapses in the dorsal cochlear nucleus. J Neurophysiol 76:1639-56
Manis, P B; Spirou, G A; Wright, D D et al. (1994) Physiology and morphology of complex spiking neurons in the guinea pig dorsal cochlear nucleus. J Comp Neurol 348:261-76