Dr. Kukuruzinska's research focuses on the regulation of protein N- glycosylation. Her work has identified the first gene, ALG7, in the dolichol pathway of protein N-glycosylation as one of the determinants of the N-glycosylation characteristics of proteins and cells. Recently, she has shown that ALG7 is an early growth-response gene and that it is progressively downregulated with the normal development of the submandibular gland (SMG). The proposed research plan is to study ALG7 expression in differentiating acinar and ductal cells during the hamster SMG development, with the emphasis on the ALG7 transcript diversity and the activity of the protein product, GPT.
| Fernandes, R P; Cotanche, D A; Lennon-Hopkins, K et al. (1999) Differential expression of proliferative, cytoskeletal, and adhesive proteins during postnatal development of the hamster submandibular gland. Histochem Cell Biol 111:153-62 |
| Lennon, K; Bird, A; Kukuruzinska, M A (1997) Deregulation of the first N-glycosylation gene, ALG7, perturbs the expression of G1 cyclins and cell cycle arrest in Saccharomyces cerevisiae. Biochem Biophys Res Commun 237:562-5 |
| Lennon, K; Bird, A; Chen, Y F et al. (1997) The dual role of mRNA half-lives in the expression of the yeast ALG7 gene. Mol Cell Biochem 169:95-106 |
| Mota, O M; Huang, G T; Kukuruzinska, M A (1994) Developmental regulation and tissue-specific expression of hamster dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT). Biochem Biophys Res Commun 204:284-91 |
