Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Modified Research Career Development Award (K04)
Project #
5K04GM000614-04
Application #
2165976
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Yeager, M; Carrington, M; Hughes, A L (2000) Class I and class II MHC bind self peptide sets that are strikingly different in their evolutionary characteristics. Immunogenetics 51:15-Aug
Verra, F; Hughes, A L (2000) Evidence for ancient balanced polymorphism at the Apical Membrane Antigen-1 (AMA-1) locus of Plasmodium falciparum. Mol Biochem Parasitol 105:149-53
Verra, F; Hughes, A L (1999) Biased amino acid composition in repeat regions of Plasmodium antigens. Mol Biol Evol 16:627-33
Hughes, A L (1999) Phylogenies of developmentally important proteins do not support the hypothesis of two rounds of genome duplication early in vertebrate history. J Mol Evol 48:565-76
Hughes, A L (1999) Evolution of the arthropod prophenoloxidase/hexamerin protein family. Immunogenetics 49:106-14
Yeager, M; Hughes, A L (1999) Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution. Immunol Rev 167:45-58
Hughes, A L; Yeager, M (1999) Coevolution of the mammalian chemokines and their receptors. Immunogenetics 49:115-24
da Silva, J; Hughes, A L (1999) Molecular phylogenetic evidence of cytotoxic T lymphocyte (CTL) selection on human immunodeficiency virus type 1 (HIV-1) Mol Biol Evol 16:1420-2
Hughes, A L (1999) Evolutionary diversification of the mammalian defensins. Cell Mol Life Sci 56:94-103
Hughes, A L; Yeager, M (1998) Natural selection and the evolutionary history of major histocompatibility complex loci. Front Biosci 3:d509-16

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