The general objective of the proposed research is to develop a unified theory of the evolution of intraspecific interactions built upon the axioms of population genetics. Most human diseases, pathogens and parasites are transmitted during social interactions. The theory to be developed studies the effects of these interactions on the biological fitness of the individuals and predicts how these effects have evolved. Four specific projects are proposed all relating to this general theme. First, since many social groups are small and centered around the family or more extended kinship ties (this is most certainly true of the recent evolutionary past of the human species), the effects of finite population size on the evolution of interactions is to be studied in family-structured populations. A variety of techniques will be used including computer simulation and analytic analysis of stochastic models. Second, a methodology is proposed to study the evolution of specific genetic systems which are conducive to certain social interactions. Third, since the most common interactions in most species is mating between the sexes, the evolution of sexual dimorphism is to be studied by techniques based on quantitative genetics and the theory of sexual selection. Fourth, it is proposed that a more unified theory of social evolution can be constructed around the idea of """"""""interaction structure"""""""". The idea of interaction structure encorporates both interactions in kin-structured populations and interactions among individuals that can modify their activities through learning. Both learning and kinship are especially relevant to the evolution of interactions between humans.
| Wojciechowski, M F; Hoelzer, M A; Michod, R E (1989) DNA repair and the evolution of transformation in Bacillus subtilis. II. Role of inducible repair. Genetics 121:411-22 |
| Hopf, F A; Michod, R E; Sanderson, M J (1988) The effect of the reproductive system on mutation load. Theor Popul Biol 33:243-65 |
| Michod, R E; Wojciechowski, M F; Hoelzer, M A (1988) DNA repair and the evolution of transformation in the bacterium Bacillus subtilis. Genetics 118:31-9 |
| Bernstein, H; Hopf, F A; Michod, R E (1987) The molecular basis of the evolution of sex. Adv Genet 24:323-70 |
| Bernstein, H; Byerly, H C; Hopf, F A et al. (1985) Sex and the emergence of species. J Theor Biol 117:665-90 |
| Bernstein, H; Byerly, H C; Hopf, F A et al. (1985) Genetic damage, mutation, and the evolution of sex. Science 229:1277-81 |
| Bernstein, H; Byerly, H C; Hopf, F A et al. (1985) The evolutionary role of recombinational repair and sex. Int Rev Cytol 96:1-28 |
