The overall objective of this project is to obtain a better understanding of the basic mechanisms subserving the control of ventilation and regulation of airway smooth muscle tone. The first project constitutes and effort to control each of three sensory receptor systems independently (pulmonary stretch receptors and 02-and CO2-chemoreceptors) so that their interactions in modulating respiratory activity may be investigated. I will determine the relationships of phrenic and para-recurrent laryngeal nerve activities and tracheal caliber to lung stretch at various constant levels of 02- and CO2- chemical drive in anesthetized dogs. The role of carotid bodies and the influence of anesthesia on these relationships will be investigated. In a second project, interactions between exercise and other factors which affect the control of ventilation will be investigated. In awake goats, the ventilatory response to exercise will be assessed during various acute and chronic treatments which alter resting ventilation and blood gases. The role of chemoreceptors in these responses will be determined. Specific attention will be devoted to the mechanism of hypoxia-exercise interactions in ventilatory control using an experimental preparation which allows perfusion of the carotid body chemoreceptors to be isolated from the rest of the body in an awake exercising animal.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL001494-02
Application #
3073815
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1985-07-01
Project End
1990-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Martin, P A; Mitchell, G S (1993) Long-term modulation of the exercise ventilatory response in goats. J Physiol 470:601-17
Mitchell, G S; Sloan, H E; Jiang, C et al. (1992) 5-Hydroxytryptophan (5-HTP) augments spontaneous and evoked phrenic motoneuron discharge in spinalized rats. Neurosci Lett 141:75-8
Douse, M A; Mitchell, G S (1992) Effects of vagotomy on ventilatory responses to CO2 in alligators. Respir Physiol 87:63-76
Douse, M A; Mitchell, G S (1992) Episodic breathing in alligators: role of sensory feedback. Respir Physiol 87:77-90
Jiang, C; Mitchell, G S; Lipski, J (1991) Prolonged augmentation of respiratory discharge in hypoglossal motoneurons following superior laryngeal nerve stimulation. Brain Res 538:215-25
Douse, M A; Mitchell, G S (1991) Time course of temperature effects on arterial acid-base status in Alligator mississippiensis. Respir Physiol 83:87-102
Warner, M M; Mitchell, G S (1991) Role of catecholamines and beta-receptors in ventilatory response during hypoxic exercise. Respir Physiol 85:41-53
Mitchell, G S; Douse, M A; Foley, K T (1990) Receptor interactions in modulating ventilatory activity. Am J Physiol 259:R911-20
Mitchell, G S (1990) Ventilatory control during exercise with increased respiratory dead space in goats. J Appl Physiol 69:718-27
Pizarro, J; Ludders, J W; Douse, M A et al. (1990) Halothane effects on ventilatory responses to changes in intrapulmonary CO2 in geese. Respir Physiol 82:337-47

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