Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL002520-02
Application #
3074501
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1990-07-01
Project End
1995-06-30
Budget Start
1991-07-26
Budget End
1992-06-30
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
Other Domestic Higher Education
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Roca, T P; Pigott, J D; Clarkson, C W et al. (1996) L-type calcium current in pediatric and adult human atrial myocytes: evidence for developmental changes in channel inactivation. Pediatr Res 40:462-8
Clarkson, C W; Xu, Y Q; Chang, C et al. (1996) Analysis of the ionic basis for cocaine's biphasic effect on action potential duration in guinea-pig ventricular myocytes. J Mol Cell Cardiol 28:667-78
Crumb Jr, W J; Pigott, J D; Clarkson, C W (1995) Comparison of Ito in young and adult human atrial myocytes: evidence for developmental changes. Am J Physiol 268:H1335-42
Crumb Jr, W J; Pigott, J D; Clarkson, C W (1995) Description of a nonselective cation current in human atrium. Circ Res 77:950-6
Crumb Jr, W J; Clarkson, C W (1995) The pH dependence of cocaine interaction with cardiac sodium channels. J Pharmacol Exp Ther 274:1228-37
Xu, Y Q; Crumb Jr, W J; Clarkson, C W (1994) Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels. J Pharmacol Exp Ther 271:319-25
Clarkson, C W; Chang, C; Stolfi, A et al. (1993) Electrophysiological effects of high cocaine concentrations on intact canine heart. Evidence for modulation by both heart rate and autonomic nervous system. Circulation 87:950-62
Crumb Jr, W J; Clarkson, C W (1992) Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes. J Pharmacol Exp Ther 261:910-7
Xu, Y Q; Pickoff, A S; Clarkson, C W (1992) Developmental changes in the effects of lidocaine on sodium channels in rat cardiac myocytes. J Pharmacol Exp Ther 262:670-6
Xu, Y Q; Pickoff, A S; Clarkson, C W (1991) Evidence for developmental changes in sodium channel inactivation gating and sodium channel block by phenytoin in rat cardiac myocytes. Circ Res 69:644-56