Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL002710-04
Application #
2210425
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-12-15
Project End
1995-08-31
Budget Start
1994-12-01
Budget End
1995-08-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Sun, D; Funk, C D (1996) Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem 271:24055-62
Funk, C D (1996) The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. Biochim Biophys Acta 1304:65-84
Chen, X S; Naumann, T A; Kurre, U et al. (1995) cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase. J Biol Chem 270:17993-9
Funk, C D; Chen, X S; Kurre, U et al. (1995) Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene. Adv Prostaglandin Thromboxane Leukot Res 23:145-50
Chen, X S; Kurre, U; Jenkins, N A et al. (1994) cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem 269:13979-87
Kuchinke, W; Funk, C D (1994) Fibronectin-induced cell spreading and down-regulation of 12-lipoxygenase expression in megakaryocytic DAMI cells. Biochem Biophys Res Commun 204:606-12
Funk, C D; Kurre, U; Griffis, G (1994) Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions. Ann N Y Acad Sci 714:253-8
Romano, M; Chen, X S; Takahashi, Y et al. (1993) Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J 296 ( Pt 1):127-33
Funk, C D (1993) Molecular biology in the eicosanoid field. Prog Nucleic Acid Res Mol Biol 45:67-98
Chen, X S; Funk, C D (1993) Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies. FASEB J 7:694-701

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