Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL002832-04
Application #
2210639
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Boxrud, P D; Fay, W P; Bock, P E (2000) Streptokinase binds to human plasmin with high affinity, perturbs the plasmin active site, and induces expression of a substrate recognition exosite for plasminogen. J Biol Chem 275:14579-89
Anderson, P J; Nesset, A; Dharmawardana, K R et al. (2000) Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation. J Biol Chem 275:16435-42
Boxrud, P D; Bock, P E (2000) Streptokinase binds preferentially to the extended conformation of plasminogen through lysine binding site and catalytic domain interactions. Biochemistry 39:13974-81
Anderson, P J; Nesset, A; Dharmawardana, K R et al. (2000) Characterization of proexosite I on prothrombin. J Biol Chem 275:16428-34
Dharmawardana, K R; Olson, S T; Bock, P E (1999) Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments. J Biol Chem 274:18635-43
Dharmawardana, K R; Bock, P E (1998) Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine proteinase Biochemistry 37:13143-52
Colwell, N S; Blinder, M A; Tsiang, M et al. (1998) Allosteric effects of a monoclonal antibody against thrombin exosite II. Biochemistry 37:15057-65
Bock, P E; Olson, S T; Bjork, I (1997) Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I. J Biol Chem 272:19837-45
Hogg, P J; Bock, P E (1997) Modulation of thrombin and heparin activities by fibrin. Thromb Haemost 77:424-33
Bock, P E; Day, D E; Verhamme, I M et al. (1996) Analogs of human plasminogen that are labeled with fluorescence probes at the catalytic site of the zymogen. Preparation, characterization, and interaction with streptokinase. J Biol Chem 271:1072-80

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