The proposed research seeks to develop in vitro models of blood molecules that may be involved in this process by i) determining how murine endothelial cells derived from transgenic mouse tumors model and interact with normal endothelial cells; ii) determining if cystic embryoid bodies that are differentiated in vitro from mouse embryonic stem cells mimic the mouse yolk sac in the expression pattern of various molecules, iii) determining the sensitivity of in vitro vascular development to exogenous factors, and iv) identifying novel genes that may be involved in vascular development.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
1K04HL002908-01
Application #
3074579
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-05-14
Project End
1998-04-30
Budget Start
1993-05-14
Budget End
1994-04-30
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599