Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL003042-03
Application #
2210989
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Seshasayee, D; Gaines, P; Wojchowski, D M (1998) GATA-1 dominantly activates a program of erythroid gene expression in factor-dependent myeloid FDCW2 cells. Mol Cell Biol 18:3278-88
Gregory, R C; Jiang, N; Todokoro, K et al. (1998) Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization. Blood 92:1104-18
Joneja, B; Chen, H C; Seshasayee, D et al. (1997) Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells. Blood 90:3533-45
Joneja, B; Wojchowski, D M (1997) Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain. J Biol Chem 272:11176-84
Reese, T T; Gregory, R C; Sharlow, E R et al. (1997) Epo-induced hemoglobinization of SKT6 cells is mediated by minimal cytoplasmic domains of the Epo or prolactin receptors without modulation of GATA-1 or EKLF. Growth Factors 14:161-76
Sharlow, E R; Pacifici, R; Crouse, J et al. (1997) Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells. Blood 90:2175-87
Gregory, R C; Taxman, D J; Seshasayee, D et al. (1996) Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined erythroid promoters. Blood 87:1793-801
Jiang, N; He, T C; Miyajima, A et al. (1996) The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera. J Biol Chem 271:16472-6
He, T C; Jiang, N; Zhuang, H et al. (1995) Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway. J Biol Chem 270:11055-61
Zhuang, H; Niu, Z; He, T C et al. (1995) Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. J Biol Chem 270:14500-4

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