Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
7K04HL003229-02
Application #
2211377
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-03-15
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Wagner, M R; Keane, D M; Melchor, J P et al. (2000) Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa. Biochemistry 39:7420-7
Melchor, J P; Van Nostrand, W E (2000) Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. J Biol Chem 275:9782-91
Melchor, J P; McVoy, L; Van Nostrand, W E (2000) Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein. J Neurochem 74:2209-12
Davis, J; Cribbs, D H; Cotman, C W et al. (1999) Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid 6:157-64
Van Nostrand, W E; Porter, M (1999) Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity. Biochemistry 38:11570-6
Temann, U A; Geba, G P; Rankin, J A et al. (1998) Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 188:1307-20
Verbeek, M M; de Waal, R M; Schipper, J J et al. (1997) Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J Neurochem 68:1135-41
Davis, J; Van Nostrand, W E (1996) Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein. Proc Natl Acad Sci U S A 93:2996-3000
Davis-Salinas, J; Van Nostrand, W E (1995) Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells. J Biol Chem 270:20887-90
Saporito-Irwin, S M; Van Nostrand, W E (1995) Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid beta-protein. J Biol Chem 270:26265-9

Showing the most recent 10 out of 12 publications