The long term objective is to understand the physiology and pharmacology of the neural system that transmit and modulate pain.
The specific aim i s to determine the elecrical properties of isolated spinothalamic and trigeminothalamic cells (dorsal horn projection cells), and the mode of actions of a number of transmitter substances on these cells. The objectives of these experiments are (1) to determine the voltage dependent properties of identified projection neurons and (2) to characterize the actions and interactions of amino acids, peptides and biogenic amines on these cells. The ionic currents of identified single projection cells will be measured under voltage clamp conditions. Patch pipette voltage clamp technique will be used. The fundamental knowledge obtained from these experiments will be essential in defining the mechanisms of action of the putative transmitters in spinothalamic cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Modified Research Career Development Award (K04)
Project #
5K04NS001050-02
Application #
3074881
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1987-06-01
Project End
1992-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555