Despite the """"""""demographic imperative"""""""" of a rapidly increasing older US population and rising cancer rates with advancing age, there is a shortage of researchers trained to address the growing cancer control needs of this heterogeneous older age group. Dr. Mandelblatt is one of the few scientists in the US with this expertise. In the current application, Dr. Mandelblatt seeks to renew her Senior Cancer Control Scientist Award to develop new research paradigms and mentor the next generation of scientists focused on improving cancer outcomes for the growing older population. In the first four years of this award the candidate has made considerable progress in developing new research on chemotherapy decisions and mentoring junior investigators as evidenced by competing for 4 new peer-reviewed grants and continuing 1 grant, publishing more than 40 high profile publications, integrating research on older women into national cancer screening guidelines, mentoring 9 investigators, and facilitating mentored faculty in their publication of 59 papers and receipt of 19 new grant awards. This high level of progress would not have been possible without the protected time afforded by the original award. ? ? The goals for this new award are to: 1) contribute new knowledge about the risks of and outcomes from use of systematic adjuvant therapy in older women with breast cancer by: a) using data from an established cohort of older women to understand how systemic treatment affects quality of life, b) conducting new research to develop an index of """"""""physiological age"""""""" to predict toxicity of chemotherapy among older breast cancer patients, and c) incorporating these data into existing simulation models to inform clinical and policy efforts to enhance the quality and cost-effectiveness of care for older women, 2) to maintain databases from research projects and make them available to trainees for the conduct of new studies about variations in breast cancer treatment, toxicity, and outcomes, and 3) to train and support young investigators. Overall, Dr. Mandelblatt is an established researcher who has demonstrated a sustained, high level of research and mentoring productivity. She has made important scientific contributions to the field and has made outstanding progress in the first grant period. Continuation of this award will allow Dr. Mandelblatt to have sufficient protected time to train new investigators and develop new research innovations to advance the science of cancer control at the intersection of aging. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Award (K05)
Project #
5K05CA096940-07
Application #
7425102
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
2002-08-16
Project End
2012-06-30
Budget Start
2008-08-01
Budget End
2009-06-30
Support Year
7
Fiscal Year
2008
Total Cost
$157,364
Indirect Cost
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Huei-Yu Wang, Judy; Ma, Grace X; Liang, Wenchi et al. (2018) Physician Intervention and Chinese Americans' Colorectal Cancer Screening. Am J Health Behav 42:13-26
Mandelblatt, Jeanne S; Cai, Ling; Luta, George et al. (2017) Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance). Breast Cancer Res Treat 164:107-117
Kimmick, Gretchen G; Major, Brittny; Clapp, Jonathan et al. (2017) Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503). Breast Cancer Res Treat 163:391-398
Bluethmann, Shirley M; Alfano, Catherine M; Clapp, Jonathan D et al. (2017) Cognitive function and discontinuation of adjuvant hormonal therapy in older breast cancer survivors: CALGB 369901 (Alliance). Breast Cancer Res Treat 165:677-686
Durá-Ferrandis, Estrella; Mandelblatt, Jeanne S; Clapp, Jonathan et al. (2017) Personality, coping, and social support as predictors of long-term quality-of-life trajectories in older breast cancer survivors: CALGB protocol 369901 (Alliance). Psychooncology 26:1914-1921
Chang, Yaojen; Near, Aimee M; Butler, Karin M et al. (2016) Economic Evaluation Alongside a Clinical Trial of Telephone Versus In-Person Genetic Counseling for BRCA1/2 Mutations in Geographically Underserved Areas. J Oncol Pract 12:59, e1-13
Mandelblatt, Jeanne S; Clapp, Jonathan D; Luta, Gheorghe et al. (2016) Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance). Cancer 122:3555-3563
Neugut, Alfred I; Hillyer, Grace Clarke; Kushi, Lawrence H et al. (2016) A prospective cohort study of early discontinuation of adjuvant chemotherapy in women with breast cancer: the breast cancer quality of care study (BQUAL). Breast Cancer Res Treat 158:127-138
Greenlee, Heather; Neugut, Alfred I; Falci, Laura et al. (2016) Association Between Complementary and Alternative Medicine Use and Breast Cancer Chemotherapy Initiation: The Breast Cancer Quality of Care (BQUAL) Study. JAMA Oncol 2:1170-6
van Ravesteyn, Nicolien T; van Lier, Lisanne; Schechter, Clyde B et al. (2015) Transition from film to digital mammography: impact for breast cancer screening through the national breast and cervical cancer early detection program. Am J Prev Med 48:535-42

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