This competing continuation of a Senior Scientist Award (K05) will allow the applicant to conduct research on cessation and reduction of tobacco and marijuana use and on new methods to treat nicotine and cannabis dependence. The K05 would allow the PI to continue leadership roles in organizations interested in tobacco research and tobacco control and to continue science education activities such as mentoring and teaching. The applicant's past research contributions include description of the nicotine withdrawal syndrome, psychiatric co-morbidity with nicotine dependence, abuse liability of nicotine replacement, the role of expectancies in nicotine effects, caffeine reinforcement and dependence, and harm reduction approaches to nicotine dependence. The applicant founded the Human Behavioral Pharmacology Laboratory at the University of Vermont (UVM) and co-founded the Society for Research on Nicotine and Tobacco and the Association for the Treatment of Tobacco Use and Dependence. In the prior K05, the applicant averaged 13 published papers/yr of which he was first author on 9/yr and of which 7/yr were empirical studies. UVM has several resources to aid the applicant to learn new disciplines and methods;e.g. UVM currently has 25 NIH grants on drug abuse across 13 Pis. This continuation proposes tobacco studies to a) compare the efficacy of NRT-assisted abrupt vs gradual cessation, b) test a cannabinoid antagonist for smoking cessation, c) test a computer mediated clinical decision support system to help clinicians treat tobacco dependence, d) describe why the large majority of smokers do not seek free treatment and e) comprehensively review the world literature on the nicotine withdrawal syndrome. The continuation proposes a new line of research on marijuana to f) describe the natural history of attempts to stop or reduce marijuana use, g) determine if the marijuana withdrawal syndrome is due to THC deprivation, h) directly compare the clinical significance of marijuana and tobacco withdrawal syndromes, i) describe marijuana withdrawal in treatment seekers and j) describe marijuana withdrawal in adolescent marijuana users. The continuation will also include collaborating with other drug abuse researchers at UVM and elsewhere. The applicant will continue to mentor 4-6 students/yr and to be actively engaged in media and policy initiatives.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000490-10
Application #
7675466
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2000-09-01
Project End
2010-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
10
Fiscal Year
2009
Total Cost
$138,510
Indirect Cost
Name
University of Vermont & St Agric College
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Carpenter, Matthew J; Hughes, John R; Gray, Kevin M et al. (2011) Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med 171:1901-7
Hughes, John R (2011) The hardening hypothesis: is the ability to quit decreasing due to increasing nicotine dependence? A review and commentary. Drug Alcohol Depend 117:111-7
Callas, Peter W; Solomon, Laura J; Hughes, John R et al. (2010) The influence of response mode on study results: offering cigarette smokers a choice of postal or online completion of a survey. J Med Internet Res 12:e46
Hughes, John R (2010) A quantitative estimate of the clinical significance of treating tobacco dependence. Am J Prev Med 39:285-6
Hughes, John R; Solomon, Laura J; Livingston, Amy E et al. (2010) A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit. Drug Alcohol Depend 111:105-13
Hughes, John R; Suiter, Catherine; Marcy, Theodore (2010) Use and outcomes of a state-funded in-person counselling program. Tob Control 19:260
Hughes, John R (2009) Ethical concerns about non-active conditions in smoking cessation trials and methods to decrease such concerns. Drug Alcohol Depend 100:187-93
Hughes, John R (2009) How confident should we be that smoking cessation treatments work? Addiction 104:1637-40
Solomon, Laura J; Hughes, John R; Livingston, Amy et al. (2009) Cognitive barriers to calling a smoking quitline. Nicotine Tob Res 11:1339-46
Hughes, John R (2009) Smokers' beliefs about the inability to stop smoking. Addict Behav 34:1005-9

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