Abstract

This is an application for a Geriatrics Leadership Academic Award. In the application, the candidate describes activities to promote, coordinate and enhance aging research and research training at The Medical College of Pennsylvania. To accomplish this, the candidate will: (1) Develop a campus-wide Center as the focal point for communication and coordination of activities in aging. (2) Organize and promote collaborative research projects including basic science and clinical science projects. (3) Develop and promote a multidisciplinary pilot research program on aging. (4) Develop research training programs on aging including NIA Complementary research training grants for training grants already in existence at The Medical College of Pennsylvania and summer research fellowships for medical students. (5) Promote the expansion of resources for research on aging at The Medical College of Pennsylvania. (6) Expand his breath and depth in gerontology and geriatrics by continuing to learn molecular biology and its application to the problems of aging and by consulting with the directors of outstanding geriatrics programs to become better acquainted with the design and function of successful programs. This experience will enable the candidate to help in the planning process for the expansion of the Geriatrics Program at The Medical College of Pennsylvania.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07AG000532-03
Application #
3076678
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1991-08-07
Project End
1994-07-31
Budget Start
1993-09-01
Budget End
1994-07-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Allegheny University of Health Sciences
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129

  Publications

Gao, E; Snyder, D L; Roberts, J et al. (1998) Age-related decline in beta adrenergic and adenosine A1 receptor function in the heart are attenuated by dietary restriction. J Pharmacol Exp Ther 285:186-92
Gao, E; Snyder, D L; Johnson, M D et al. (1997) The effect of age on adenosine A1 receptor function in the rat heart. J Mol Cell Cardiol 29:593-602
Giusti, P; Lipartiti, M; Franceschini, D et al. (1996) Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J 10:891-6
Manev, H; Uz, T; Kharlamov, A et al. (1996) Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J 10:1546-51
Kharlamov, A; Uz, T; Joo, J Y et al. (1996) Pharmacological characterization of apoptotic cell death in a model of photothrombotic brain injury in rats. Brain Res 734:1-9
Uz, T; Giusti, P; Franceschini, D et al. (1996) Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats. Neuroscience 73:631-6
Pignolo, R J; Rotenberg, M O; Cristofalo, V J (1994) Alterations in contact and density-dependent arrest state in senescent WI-38 cells. In Vitro Cell Dev Biol Anim 30A:471-6
Kunder, S C; Wu, L; Morahan, P S (1993) Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anh Antiviral Res 21:233-45
Horwitz, J; Davis, L L (1993) The substrate specificity of brain microsomal phospholipase D. Biochem J 295 ( Pt 3):793-8
De Tata, V; Ptasznik, A; Cristofalo, V J (1993) Effect of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts. Exp Cell Res 205:261-9