The overall goal of this Academic Career Leadership Award is to develop an outstanding research and educational program on Alzheimer's disease (AD) and other neurodegenerative disorders at the State University of New York, Health Science Center at Brooklyn (Downstate). We plan to build upon the existing strengths at Downstate and the unique demographics of its surrounding community. These include the neuroscience program with its emphasis on hippocampal pathophysiology, the large population of Caribbean American, African American, and other minority groups in Brooklyn, and the special interests of the PI, including the overlap and heterogeneity of AD, Parkinson's disease and other neurodegenerative disorders.
Our specific aims are to (1) establish an infrastructure to support the development of an institutional research center on AD and related neurodegenerative disorders; (2) develop mechanisms that will bring new investigators to the field, enable established investigators to channel their expertise towards the field, encourage collaborations, and support pilot studies; (3) stimulate interest and collaborations in AD-related research within the scientific community through educational programs and related experiences; and (4) promote awareness of AD in the lay and professional community through outreach and educational programs. The candidate, Dr. Suzanne Mirra, is well qualified to lead this initiative. An experienced and respected neuropathologist working on AD and other neurodegenerative disorders, Dr. Mirra was the director and principal investigator of the Alzheimer's Disease Center at her former institution. She led the neuropathology arm of CERAD (Consortium to Establish a Registry for AD), the NIA longitudinal study, in standardizing the neuropathological evaluation of AD. A nationally recognized leader in neuropathology, she is Founding Chair of the Neuropathology Committee of the College of American Pathologists and President-Elect of the American Association of Neuropathologists. Dr. Mirra has forged strong ties in the lay community, such as her involvement with the national board and regional chapters of the Alzheimer's Association. Moreover, she is an outstanding communicator as well as a committed and innovative educator with a demonstrated track record of outreach to non-white minorities. This Academic Career Leadership Award, along with strong institutional commitment, will enable Dr. Mirra and collaborators to build a thriving research program on Alzheimer's disease and related neurodegenerative disorders at Downstate.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07AG000959-05
Application #
6717628
Study Section
Special Emphasis Panel (ZAG1-BJB-4 (O5))
Program Officer
Snyder, Stephen D
Project Start
2000-02-01
Project End
2005-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
5
Fiscal Year
2004
Total Cost
$108,000
Indirect Cost
Name
Suny Downstate Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Cai, Huaibin; Liu, Guoxiang; Sun, Lixin et al. (2014) Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease. Transl Neurodegener 3:27
Liu, Guoxiang; Yu, Jia; Ding, Jinhui et al. (2014) Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. J Clin Invest 124:3032-46
Lin, Xian; Parisiadou, Loukia; Sgobio, Carmelo et al. (2012) Conditional expression of Parkinson's disease-related mutant ?-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1. J Neurosci 32:9248-64
Ye, Weizhen; Blain, Stacy W (2010) S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons. Brain 133:2295-312
Chandran, Jayanth S; Lin, Xian; Zapata, Agustin et al. (2008) Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis 29:505-14
Cai, Huaibin; Shim, Hoon; Lai, Chen et al. (2008) ALS2/alsin knockout mice and motor neuron diseases. Neurodegener Dis 5:359-66
Wang, Lizhen; Shim, Hoon; Xie, Chengsong et al. (2008) Activation of protein kinase C modulates BACE1-mediated beta-secretase activity. Neurobiol Aging 29:357-67
Wang, Lizhen; Xie, Chengsong; Greggio, Elisa et al. (2008) The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci 28:3384-91
Erie, Elizabeth A; Shim, Hoon; Smith, Aleah L et al. (2007) Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function. J Neuroimmunol 182:226-31
Lin, Xian; Shim, Hoon; Cai, Huaibin (2007) Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice. Neurobiol Aging 28:1628-30

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