Native American women have a 2-3 fold higher incidence of invasive cervical cancer and mortality compared with non-Hispanic white women. The causes of these persistently higher rates of cervical cancer remain unknown. PAP smear screening, HPV infection, sexual history and nutritional status have been related to cervical cancer in other studies. To date, tribal specific incidence and mortality rates for cervical cancer among Native Americans living in Arizona, such as the Hopi, have not been published. The purpose of this investigation is to: 1. Identify cultural and behavioral barriers to cervical cancer control and prevention among Hopi women in the two age groups 18-50 and greater than 50. 2. Develop and evaluate an intervention to increase cervical cancer screening among Hopi women, through a lay health educator cancer education program. 3. Determine the virologic and nutritional risk factors for cervical dysplasia and cancer among Hopi women. Information from these investigations will be used to develop culturally appropriate education materials, training programs for lay health educators and guide for physicians in the prevention and control of cervical cancer among Hopi women specifically, and Native American women in general. This proposal for research will be the major component of a 5 year Academic Investigator Award in which cancer prevention and epidemiology will be the focus. These studies along with continued course work in advanced epidemiology and biostatistics, and experience in teaching will provide the experience and expertise needed to function as a successful, independent investigator in the future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA060885-03
Application #
2101662
Study Section
Cancer Education Review Committee (CEC)
Project Start
1993-09-30
Project End
1998-09-29
Budget Start
1995-09-30
Budget End
1996-09-29
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arizona
Department
Family Medicine
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Coe, Kathryn; Martin, Lorencita; Nuvayestewa, Leon et al. (2007) Predictors of Pap test use among women living on the Hopi reservation. Health Care Women Int 28:764-81
Flores, Roberto; Papenfuss, Mary; Klimecki, Walter T et al. (2006) Cross-sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia. Int J Cancer 118:1187-93
Coe, Kathryn; Attakai, Agnes; Papenfuss, Mary et al. (2004) Traditionalism and its relationship to disease risk and protective behaviors of women living on the Hopi reservation. Health Care Women Int 25:391-410
Giuliano, Anna R; Papenfuss, Mary; De Galaz, Elena Mendez Brown et al. (2004) Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border. Int J Cancer 109:112-8
Baldwin, S B; Djambazov, B; Papenfuss, M et al. (2004) Chlamydial infection in women along the US-Mexico border. Int J STD AIDS 15:815-21
Inserra, P; Abrahamsen, M; Papenfuss, M et al. (2003) Ethnic variation of the P53 codon 72 polymorphism, HPV persistence, and cervical cancer risk. Int J STD AIDS 14:800-4
Garcia, Francisco; Mendez de Galaz, Elena; Baldwin, Susie et al. (2003) Factors that affect the quality of cytologic cervical cancer screening along the Mexico-United States border. Am J Obstet Gynecol 189:467-72
Sedjo, Rebecca L; Papenfuss, Mary R; Craft, Neal E et al. (2003) Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States). Cancer Causes Control 14:319-26
Sedjo, Rebecca L; Fowler, Brenda M; Schneider, Achim et al. (2003) Folate, vitamin B12, and homocysteine status. findings of no relation between human papillomavirus persistence and cervical dysplasia. Nutrition 19:497-502
Sedjo, Rebecca L; Roe, Denise J; Abrahamsen, Martha et al. (2002) Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection. Cancer Epidemiol Biomarkers Prev 11:876-84

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