) This application for a Preventive Oncology Academic Award will allow the applicant to develop as an independent researcher engaged in epidemiologic studies of cancer etiology and prevention in a defined population-based, managed care setting. This application is jointly sponsored by faculty from the Center for Health Studies at Group Health Cooperative, the Cancer Prevention Research Program of the Fred Hutchinson Cancer Research Center, and the Department of Epidemiology at the University of Washington. In this setting, Dr. Mandelson plans to pursue a four-year program that consists of academic activities, post-graduate teaching, advanced training, and three research projects. Research Projects Proposed: 1. A cross-sectional study of breast cell proliferation and mammographic density in women undergoing excisional breast biopsy. 2. An evaluation of mammography performance in elderly women. 3. A case-control study of hormone replacement therapy and adenomatous polyps. This plan is focused on three specific areas of interest: the use of biomarkers in cancer epidemiology research, cancer screening evaluation, and cancer etiology. Completion of this program will provide a strong foundation for a successful independent career in cancer control research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
3K07CA071869-04S1
Application #
6356667
Study Section
Cancer Research Manpower and Education Review Committee (CRME)
Program Officer
Gorelic, Lester S
Project Start
1996-09-06
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2001-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$91,042
Indirect Cost
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
Taplin, Stephen H; Rutter, Carolyn M; Finder, Charles et al. (2002) Screening mammography: clinical image quality and the risk of interval breast cancer. AJR Am J Roentgenol 178:797-803
Rutter, C M; Mandelson, M T; Laya, M B et al. (2001) Changes in breast density associated with initiation, discontinuation, and continuing use of hormone replacement therapy. JAMA 285:171-6
Mandelson, M T; Curry, S J; Anderson, L A et al. (2000) Colorectal cancer screening participation by older women. Am J Prev Med 19:149-54
Newcomb, P A; Mandelson, M T (2000) A record-based evaluation of induced abortion and breast cancer risk (United States). Cancer Causes Control 11:777-81
Mandelson, M T; Oestreicher, N; Porter, P L et al. (2000) Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers. J Natl Cancer Inst 92:1081-7
Kerlikowske, K; Carney, P A; Geller, B et al. (2000) Performance of screening mammography among women with and without a first-degree relative with breast cancer. Ann Intern Med 133:855-63
Edlefsen, K L; Mandelson, M T; McIntosh, M W et al. (1999) Prostate-specific antigen for prostate cancer screening. Do physician characteristics affect its use? Am J Prev Med 17:87-90
Mandelson, M T; LaCroix, A Z; Anderson, L A et al. (1999) Comparison of self-reported fecal occult blood testing with automated laboratory records among older women in a health maintenance organization. Am J Epidemiol 150:617-21
Porter, P L; El-Bastawissi, A Y; Mandelson, M T et al. (1999) Breast tumor characteristics as predictors of mammographic detection: comparison of interval- and screen-detected cancers. J Natl Cancer Inst 91:2020-8
Mandelson, M T; Thompson, R S (1998) Cancer screening in HMOs: program development and evaluation. Am J Prev Med 14:26-32