Although the first transfusion of blood from one animal to another was done with dogs in 1665, the current state of the art in veterinary practice is undeveloped. Most animals are transfused with blood that is neither typed nor crossmatched. That occurs because transfusion training and experience in the veterinary colleges is limited, and the species-specific blood banking reagents are not available commercially. If a transfusion medicine academic award is given to a veterinarian, it could provide the needed stimulus for more basic and applied research in comparative transfusion medicine and potentially allow the development of animal models that would be useful for human transfusion medicine. The objectives of this proposal are: 1) to develop an effective curriculum in veterinary transfusion medicine with a multidisciplinary approach that improves the skills and knowledge of graduating veterinarians; 2) to attract veterinarians into transfusion medicine teaching and research by recruiting outstanding students as Transfusion Medicine Trainees; 3) to increase the amount of research in veterinary transfusion by the candidate and to develop his educational skills through formal course work in the Department of Curriculum and Instruction at Kansas State University; 4) to increase the interest of other faculty members in transfusion medicine; 5) to increase the awareness of transfusion medicine in the veterinary profession by displays at national veterinary meetings, inclusion of questions on national examinations for general practice and specialty boards and interaction with other veterinary schools about transfusion medicine; and 6) to write a concise, practical book on veterinary transfusion medicine. The unique features of this proposal are: 1) the candidate's background, which includes training with physicians who are actively involved in blood banking, his research on animal models for human hematological diseases (particularly those of the erthrocyte), and his previous interest in transfusion medicine as evidenced by published papers in the field, 2) the strength of the Audiovisual Resource in the College of Veterinary Medicine, and the expertise in the Department of Curriculum and Instruction at Kansas State University.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07HL001877-02
Application #
3077217
Study Section
(SRC)
Project Start
1986-09-01
Project End
1991-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Kansas State University
Department
Type
Schools of Veterinary Medicine
DUNS #
City
Manhattan
State
KS
Country
United States
Zip Code
66506
Andrews, G A; Chavey, P S; Smith, J E (1992) Reactivity of lichen lectins with blood typed canine erythrocytes. Res Vet Sci 53:315-9
Steffen, D J; Elliott, G S; Leipold, H W et al. (1992) Congenital dyserythropoiesis and progressive alopecia in Polled Hereford calves: hematologic, biochemical, bone marrow cytologic, electrophoretic, and flow cytometric findings. J Vet Diagn Invest 4:31-7
Andrews, G A; Chavey, P S; Smith, J E (1992) Production, characterization, and applications of a murine monoclonal antibody to dog erythrocyte antigen 1.1. J Am Vet Med Assoc 201:1549-52
Smith, J E; Dever, M; Smith, J et al. (1992) Post-transfusion survival of 50Cr-labeled erythrocytes in neonatal foals. J Vet Intern Med 6:183-5
Andrews, G A; Chavey, P S; Smith, J E et al. (1992) N-glycolylneuraminic acid and N-acetylneuraminic acid define feline blood group A and B antigens. Blood 79:2485-91
Conboy, J G; Shitamoto, R; Parra, M et al. (1991) Hereditary elliptocytosis due to both qualitative and quantitative defects in membrane skeletal protein 4.1. Blood 78:2438-43
Stamler, J S; Vaughan, D E; Loscalzo, J (1991) Immunosuppressive therapy and lipoprotein abnormalities after cardiac transplantation. Am J Cardiol 68:389-91
Stamler, J S; Loscalzo, J (1991) The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J Am Coll Cardiol 18:1529-36
Weeks, B R; Smith, J E; Stadler, C K (1990) Effect of dietary iron content on hematologic and other measures of iron adequacy in dogs. J Am Vet Med Assoc 196:749-53
Smith, J E; Erickson, H H; Debowes, R M et al. (1989) Changes in circulating equine erythrocytes induced by brief, high-speed exercise. Equine Vet J 21:444-6

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