The proposed three-year multidisciplinary program is to foster his academic development. Specific goals are: 1. To enhance the research skills that apply to the study of mental disorders in the elderly, particularly Alzheimer's disease. 2. To understand better the phenomenology and pathogenesis of psychiatric and behavioral disturbances in patients with AD. 3. To foster development as a teacher and faculty resource in the areas of dementia and the neuropsychiatric aspects of mental disorders in the elderly. Plans proposed to achieve these goals are: 1. We will implement the Psychiatric and Behavioral Disturbances in Alzheimer's Disease project. This pilot study will test the hypothesis that behavioral changes characteristic of AD are associated with extent of dysfunction in specific brain regions. Patients with AD will undergo structured assessment of psychiatric and behavioral symptoms. Regional cerebral metabolic rates for glucose will be measured by positron emission tomography (PET). Data analysis will identify correlations between psychiatric disturbances and regional cerebral dysmetabolism. 2. We will pursue additional research training, participate in collaborative research projects, and consult with experts in geriatric mental health research. 3. We will complete additional training in clinical geriatric psychiatry and will assume important responsibilities in the Geriatric Psychiatry Outpatient program at UCLA. 4. We will share his knowledge of the neurobiological aspects of mental disorders in the elderly with medical students, physician-trainees, and fellow faculty at UCLA.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07MH000910-02
Application #
2240126
Study Section
Life Course and Prevention Research Review Committee (LCR)
Project Start
1991-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Sultzer, David L; Chen, Stephen T; Brown, Charles V et al. (2002) Subcortical hyperintensities in Alzheimer's disease: associated clinical and metabolic findings. J Neuropsychiatry Clin Neurosci 14:262-9
Harwood, Dylan G; Sultzer, David L (2002) ""Life is not worth living"": hopelessness in Alzheimer's disease. J Geriatr Psychiatry Neurol 15:38-43
Sultzer, D L; Gray, K F; Gunay, I et al. (2001) Does behavioral improvement with haloperidol or trazodone treatment depend on psychosis or mood symptoms in patients with dementia? J Am Geriatr Soc 49:1294-300
Harwood, D G; Sultzer, D L; Wheatley, M V (2000) Impaired insight in Alzheimer disease: association with cognitive deficits, psychiatric symptoms, and behavioral disturbances. Neuropsychiatry Neuropsychol Behav Neurol 13:83-8
Chen, S T; Sultzer, D L; Hinkin, C H et al. (1998) Executive dysfunction in Alzheimer's disease: association with neuropsychiatric symptoms and functional impairment. J Neuropsychiatry Clin Neurosci 10:426-32
Lavretsky, H; Sultzer, D (1998) A structured trial of risperidone for the treatment of agitation in dementia. Am J Geriatr Psychiatry 6:127-35
Sultzer, D L; Gray, K F; Gunay, I et al. (1997) A double-blind comparison of trazodone and haloperidol for treatment of agitation in patients with dementia. Am J Geriatr Psychiatry 5:60-9
Sultzer, D L; Berisford, M A; Gunay, I (1995) The Neurobehavioral Rating Scale: reliability in patients with dementia. J Psychiatr Res 29:185-91
Sultzer, D L; Mahler, M E; Cummings, J L et al. (1995) Cortical abnormalities associated with subcortical lesions in vascular dementia. Clinical and position emission tomographic findings. Arch Neurol 52:773-80
Sultzer, D L; Mahler, M E; Mandelkern, M A et al. (1995) The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 7:476-84

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