Abstract

The project is based on the hypothesis that immunotherapy is a more potent treatment than intranasal steroids for allergic rhinitis because it can more profoundly alter the immune system and reach sites beyond the nose. A double blind, placebo-controlled study is proposed. The effects of immunotherapy and intranasal steroids on the nasal response to allergen will be compared by studying mast cell activation and distribution, cellular inflammation, and allergen-induced hyperresponsiveness. In addition, immunotherapy will be compared with intranasal steroids with regard to controlling all the symptoms of allergic rhinitis such as eye irritation and sinus and pulmonary problems. The candidate will also test the hypothesis that immunotherapy alters the T cell response of the nasal mucosa to allergen from the Th2 to the Th1 profile.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI001236-02
Application #
2457629
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Baroody, F M; Assanasen, P; Chung, J et al. (2000) Hot, humid air partially inhibits the nasal response to allergen provocation. Arch Otolaryngol Head Neck Surg 126:749-54
Assanasen, P; Baroody, F M; Abbott, D J et al. (2000) Natural and induced allergic responses increase the ability of the nose to warm and humidify air. J Allergy Clin Immunol 106:1045-52
Baroody, F M; Gungor, A; deTineo, M et al. (1999) Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine. J Appl Physiol 87:1038-47
Baroody, F M; Ford, S; Proud, D et al. (1999) Relationship between histamine and physiological changes during the early response to nasal antigen provocation. J Appl Physiol 86:659-68
Assanasen, P; Baroody, F M; Naureckas, E et al. (1999) Warming of feet elevates nasal mucosal surface temperature and reduces the early response to nasal challenge with allergen. J Allergy Clin Immunol 104:285-93
Rouadi, P; Baroody, F M; Abbott, D et al. (1999) A technique to measure the ability of the human nose to warm and humidify air. J Appl Physiol 87:400-6
Baroody, F M; Rouadi, P; Driscoll, P V et al. (1998) Intranasal beclomethasone reduces allergen-induced symptoms and superficial mucosal eosinophilia without affecting submucosal inflammation. Am J Respir Crit Care Med 157:899-906
Naclerio, R M; Baroody, F (1998) Understanding the inflammatory processes in upper allergic airway disease and asthma. J Allergy Clin Immunol 101:S345-51