Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI001345-02
Application #
2057651
Study Section
Cancer Institutional Fellowship Review Committee (CT)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Adachi, S; Gottlieb, R A; Babior, B M (1998) Lack of release of cytochrome C from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells. J Biol Chem 273:19892-4
Gottlieb, R A; Babior, B M (1997) Regulation of Fas-mediated apoptosis. Curr Top Cell Regul 35:69-105
Niessen, H; Meisenholder, G W; Li, H L et al. (1997) Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood 90:4598-601
Adachi, S; Cross, A R; Babior, B M et al. (1997) Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem 272:21878-82
Krippner, A; Matsuno-Yagi, A; Gottlieb, R A et al. (1996) Loss of function of cytochrome c in Jurkat cells undergoing fas-mediated apoptosis. J Biol Chem 271:21629-36
Gottlieb, R A; Dosanjh, A (1996) Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis. Proc Natl Acad Sci U S A 93:3587-91
Gottlieb, R A; Nordberg, J; Skowronski, E et al. (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci U S A 93:654-8
Gottlieb, R A; Gruol, D L; Zhu, J Y et al. (1996) Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. J Clin Invest 97:2391-8
Meisenholder, G W; Martin, S J; Green, D R et al. (1996) Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection. J Biol Chem 271:16260-2