Medication and physician prescribing practices have a significant impact on the course of asthma. Several studies have documented that the major factors contributing to asthma morbidity are under-diagnosis and inappropriate treatment (1995 NHLBI/WHO Workshop Report). The objectives of this application are to study the relationship between asthma control and medication utilization. This application proposes to extend a retrospective analysis of the Tennessee Medicaid population to determine risk factors for asthma exacerbations requiring hospital care, to characterize medication utilization patterns that predict such events, and to develop a management scheme based on identification of medication use through a pharmacy-based drug utilization program. We hypothesize that there are timely predictors of asthma exacerbations requiring hospital care in high-risk populations, and that these predictors should be utilized in clinical practice to both identify those at risk and initiate appropriate clinical management. To test this hypothesis we will use an existing retrospective database to determine patterns of beta-agonist use and prescribing that predict asthma exacerbations requiring hospital care or corticosteroid rescue. We will then test whether these usage patterns predict asthma exacerbations using prospective data, and test a beta-agonist utilization management strategy in clinical practice. The ultimate goal of these analyses will be to (1) develop a computerized pharmacy-based drug utilization review program to identify, in a timely manner, those patients at a high risk of an asthma exacerbation, as well as physicians with high-risk patients and inadequate prescribing practices, and (2) develop a step-wise approach of asthma management based on an objective drug utilization strategy.
In specific aim #1 we propose to define medication utilization patterns that predict asthma exacerbations requiring hospital care or systemic corticosteroid rescue. We hypothesize that beta-agonist utilization is a predictor of such asthma exacerbations. To test this hypothesis we will utilize the Tennesse Medicaid Database.
In specific Aim #2 we will perform a prospective case-crossover study of medication utilization in asthma patients requiring hospitalization. We hypothesize that for high risk asthmatics requiring hospital care, quantification of beta-agonist use, rather than the standard measures of using peak expiratory flows or symptom reporting, is a better means of predicting disease exacerbation.
In specific aim #3 we propose to develop a management strategy in high risk asthma patients using medication utilization patients via a computerized pharmacy identification system and a stepwise management modality based on beta-agonist use.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI001582-05
Application #
6627950
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1999-02-01
Project End
2004-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
5
Fiscal Year
2003
Total Cost
$121,149
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Moore, Paul E; Williams, Scott M; Gebretsadik, Tebeb et al. (2008) beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation. Clin Transl Sci 1:155-61
Arnold, Donald H; Gebretsadik, Tebeb; Minton, Patricia A et al. (2008) Assessment of severity measures for acute asthma outcomes: a first step in developing an asthma clinical prediction rule. Am J Emerg Med 26:473-9
Enriquez, Rachel; Griffin, Marie R; Carroll, Kecia N et al. (2007) Effect of maternal asthma and asthma control on pregnancy and perinatal outcomes. J Allergy Clin Immunol 120:625-30
Wu, Pingsheng; Roberts 2nd, Lyman J; Shintani, Ayumi K et al. (2007) Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Free Radic Res 41:956-62
Carroll, Kecia N; Gebretsadik, Tebeb; Griffin, Marie R et al. (2007) Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics 119:1104-12
Arnold, Donald H; Gebretsadik, Tebeb; Minton, Patricia A et al. (2007) Clinical measures associated with FEV1 in persons with asthma requiring hospital admission. Am J Emerg Med 25:425-9
Whalen, Ursula; Griffin, Marie R; Shintani, Ayumi et al. (2006) Smoking rates among pregnant women in Tennessee, 1990-2001. Prev Med 43:196-9
Venarske, Daniel L; Busse, William W; Griffin, Marie R et al. (2006) The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. J Infect Dis 193:1536-43
Enriquez, Rachel; Wu, Pingsheng; Griffin, Marie R et al. (2006) Cessation of asthma medication in early pregnancy. Am J Obstet Gynecol 195:149-53
Carroll, Kecia N; Griffin, Marie R; Gebretsadik, Tebeb et al. (2005) Racial differences in asthma morbidity during pregnancy. Obstet Gynecol 106:66-72

Showing the most recent 10 out of 24 publications