Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AI069989-03
Application #
7623862
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Koshy, Rajen
Project Start
2007-06-15
Project End
2012-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
3
Fiscal Year
2009
Total Cost
$116,370
Indirect Cost

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Dibrov, Sergey M; Ding, Kejia; Brunn, Nicholas D et al. (2012) Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches. Proc Natl Acad Sci U S A 109:5223-8
Zhu, Haihong; Wong-Staal, Flossie; Lee, Haekyung et al. (2012) Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals. J Infect Dis 205:656-62
Valiaeva, Nadejda; Wyles, David L; Schooley, Robert T et al. (2011) Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication. Bioorg Med Chem 19:4616-25
Carnevali, Maia; Parsons, Jerod; Wyles, David L et al. (2010) A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site. Chembiochem 11:1364-7
Wyles, David L; Schooley, Robert T (2010) Rong's numbers: accelerating progress in HCV therapeutic research. Sci Transl Med 2:33ps25
Wyles, David L; Kaihara, Kelly A; Korba, Brent E et al. (2009) The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons. Antimicrob Agents Chemother 53:2660-2
Morrey, John D; Korba, Brent E; Beadle, James R et al. (2009) Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo. Antimicrob Agents Chemother 53:2865-70
Parsons, Jerod; Castaldi, M Paola; Dutta, Sanjay et al. (2009) Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA. Nat Chem Biol 5:823-5
Grunberger, Christian; Wyles, David L; Kaihara, Kelly A et al. (2008) 3-drug synergistic interactions of small molecular inhibitors of hepatitis C virus replication. J Infect Dis 197:42-5
Wyles, David L; Kaihara, Kelly A; Schooley, Robert T (2008) Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors. Antimicrob Agents Chemother 52:1862-4