Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AR001899-04
Application #
2077437
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Guise, T A; Yin, J J; Thomas, R J et al. (2002) Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo. Bone 30:670-6
Guise, T A (2000) Molecular mechanisms of osteolytic bone metastases. Cancer 88:2892-8
Thomas, R J; Guise, T A; Yin, J J et al. (1999) Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 140:4451-8
Lemieux, P; Harvey, J; Guise, T et al. (1999) Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in vivo. J Bone Miner Res 14:1570-5
Yin, J J; Selander, K; Chirgwin, J M et al. (1999) TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 103:197-206
Guise, T A; Mundy, G R (1998) Cancer and bone. Endocr Rev 19:18-54
Uy, H L; Mundy, G R; Boyce, B F et al. (1997) Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. Cancer Res 57:3194-9
Guise, T A (1997) Parathyroid hormone-related protein and bone metastases. Cancer 80:1572-80
Guise, T A; Mundy, G R (1996) Physiological and pathological roles of parathyroid hormone-related peptide. Curr Opin Nephrol Hypertens 5:307-15
Guise, T A; Yin, J J; Taylor, S D et al. (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98:1544-9

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