Cell Activation and Basic Calcium Phosphate Crystals

McCarthy, Geraldine M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 5K08AR001953-02
• Application #: 2077550
• Study Section: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
• Project Start: 1995-01-01
• Project End: 1999-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Medical College of Wisconsin
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 073134603
• City: Milwaukee
• State: WI
• Country: United States
• Zip Code: 53226

Publications

McCarthy, G M; Westfall, P R; Masuda, I et al. (2001) Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes. Ann Rheum Dis 60:399-406

McCarthy, G M; Cheung, H S; Abel, S M et al. (1998) Basic calcium phosphate crystal-induced collagenase production: role of intracellular crystal dissolution. Osteoarthritis Cartilage 6:205-13

McCarthy, G M; Macius, A M; Christopherson, P A et al. (1998) Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts. Ann Rheum Dis 57:56-60

McCarthy, G M; Augustine, J A; Baldwin, A S et al. (1998) Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts. Role of nuclear factor kappab, activator protein 1, and protein kinase c. J Biol Chem 273:35161-9