Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AR002214-05
Application #
6935236
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Gretz, Elizabeth
Project Start
2001-08-01
Project End
2006-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
5
Fiscal Year
2005
Total Cost
$119,548
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Agarwal, Sandeep K; Lee, David M; Kiener, Hans P et al. (2008) Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes. Arthritis Rheum 58:1044-54
Nigrovic, Peter A; Lee, David M (2007) Synovial mast cells: role in acute and chronic arthritis. Immunol Rev 217:19-37
Nigrovic, Peter A; Binstadt, Bryce A; Monach, Paul A et al. (2007) Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104:2325-30
Lee, David M; Kiener, Hans P; Agarwal, Sandeep K et al. (2007) Cadherin-11 in synovial lining formation and pathology in arthritis. Science 315:1006-10
Christmas, Peter; Tolentino, Karine; Primo, Valeria et al. (2006) Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4. J Biol Chem 281:7189-96
Kiener, Hans P; Lee, David M; Agarwal, Sandeep K et al. (2006) Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro. Am J Pathol 168:1486-99
Chen, Mei; Lam, Bing K; Kanaoka, Yoshihide et al. (2006) Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med 203:837-42
Watts, Gerald M; Beurskens, Frank J M; Martin-Padura, Ines et al. (2005) Manifestations of inflammatory arthritis are critically dependent on LFA-1. J Immunol 174:3668-75
Nigrovic, P A; Lee, D M (2005) Mast cells in autoantibody responses and arthritis. Novartis Found Symp 271:200-9; discussion 210-4
Valencia, Xavier; Higgins, Jonathan M G; Kiener, Hans P et al. (2004) Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med 200:1673-9

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